Evidence map›Paper›PMID 33912553›Full record

ArticleFrontiers in cell and developmental biology2021

Crtc1 Deficiency Causes Obesity Potentially via Regulating PPARγ Pathway in White Adipose.

Yimeng Hu, Jian Lv, Yu Fang, Qiang Luo, Yuan He, Lili Li, Mingxia Fan, Zhihua Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yimeng HuDepartment of Endocrinology, Renmin Hospital of Wuhan University, Wuhan, China.
Jian LvDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Yu FangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Qiang LuoDepartment of Endocrinology, Renmin Hospital of Wuhan University, Wuhan, China.
Yuan HeCentral Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.
Lili LiCentral Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.
Mingxia FanAnimal Center, Renmin Hospital of Wuhan University, Wuhan, China.
Zhihua WangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Renmin Hospital of Wuhan University · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is characterized by excessive fat accumulation and associated with glucose and lipid metabolism disorders. Crtc1, a transcription cofactor regulating CREB activity, has been involved in the pathogenesis of metabolic syndrome; however, the underlying mechanism remains under debate. Here we generated a Crtc1

Indexed as

adiposeCrtc1lipid metabolismobesityPparγ (peroxisome proliferator-activated receptor gamma)

Identifiers

PMID33912553
PMCPMC8075410
OpenAlexW3155050422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.