Evidence map›Paper›PMID 33912476›Full record

ArticleFrontiers in cellular and infection microbiology2021

Adjunctive S100A8/A9 Immunomodulation Hinders Ciprofloxacin Resistance in

Anne S Laulund, Franziska Schwartz, Hannah Trøstrup, Kim Thomsen, Lars Christophersen, Henrik Calum, Oana Ciofu, Niels Høiby, Claus Moser

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Anne S LaulundDepartment of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark.
Franziska SchwartzDepartment of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark.
Hannah TrøstrupDepartment of Plastic Surgery, Zealand University Hospital, Copenhagen, Denmark.
Kim ThomsenDepartment of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark.
Lars ChristophersenDepartment of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark.
Henrik CalumDepartment of Clinical Microbiology, Hvidovre Hospital, Hvidovre, Denmark.
Oana CiofuDepartment of Immunology and Microbiology (ISIM), University of Copenhagen, Copenhagen, Denmark.
Niels HøibyDepartment of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark.
Claus MoserDepartment of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark.
Copenhagen University Hospital · DKHvidovre Hospital · DKUniversity of Copenhagen · DKZealand University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Method: Full-thickness 2.9cm Results: Three mice receiving ciprofloxacin monotherapy developed resistance after 14 days. None of the mice receiving combination therapy changed resistance pattern. Sequencing of fluoroquinolone-resistance determining regions in the ciprofloxacin resistant isolates identified two high-resistant strains mutated in Conclusion: This study supports the ciprofloxacin augmenting effect and indicates a protective effect in terms of hindered ciprofloxacin resistance of adjuvant S100A8/A9 in

Indexed as

Pseudomonas InfectionsWound InfectionAnimalsAnti-Bacterial AgentsBiofilmsCiprofloxacinImmunomodulationMiceMicrobial Sensitivity TestsPseudomonas aeruginosaAnti-Bacterial AgentsCiprofloxacinbiofilmchronic woundsciprofloxacinpseudomonasresistance development

Identifiers

PMID33912476
PMCPMC8072475
OpenAlexW3156686732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.