Evidence map›Paper›PMID 33912214›Full record

ArticleFrontiers in genetics2021

Disorder of Sexual Development Males With XYY in Blood Have Exactly X/XY/XYY Mosaicism in Gonad Tissues.

Yongjia Yang, Fang Chen, Zhenqing Luo, Yu Zheng, Jiayong Zheng, Yuyan Fu, Weijian Chen, Haiyan Luo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yongjia YangThe Laboratory of Genetics and Metabolism, Hunan Children's Research Institute, Hunan Children's Hospital, University of South China, Changsha, China.
Fang ChenThe Laboratory of Genetics and Metabolism, Hunan Children's Research Institute, Hunan Children's Hospital, University of South China, Changsha, China.
Zhenqing LuoThe Laboratory of Genetics and Metabolism, Hunan Children's Research Institute, Hunan Children's Hospital, University of South China, Changsha, China.
Yu ZhengThe Laboratory of Genetics and Metabolism, Hunan Children's Research Institute, Hunan Children's Hospital, University of South China, Changsha, China.
Jiayong ZhengKey Laboratory of Obstetrics and Gynecology, Wenzhou People's Hospital, Wenzhou, China.
Yuyan FuThe Laboratory of Genetics and Metabolism, Hunan Children's Research Institute, Hunan Children's Hospital, University of South China, Changsha, China.
Weijian ChenDepartment of Pathology, Hunan Children's Hospital, University of South China, Changsha, China.
Haiyan LuoCenter for Diagnosis and Treatment of Rare Diseases, Hunan Children's Hospital, University of South China, Changsha, China.
University of South China · CNHunan Children's Hospital · CNWenzhou City People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Y chromosome represents masculinization. The extra Y chromosome of XYY patients usually leads to over-masculinization phenotypes. The occurrence of several DSD cases with XYY in blood is controversial. Is XYY associated with disorder of sex development (DSD)? What is the mechanism behind DSD in males with XYY in blood? To this end, this study retrospectively analyzed blood-karyotype data of 4,437 DSD male children and karyotypes data of 6,259 newborn males as the control. Exome sequencing (ES) was performed to test whether the patients with DSD and with XYY in blood had other variants on known DSD-genes. Testicular biopsy was performed. Fluorescence

Indexed as

DSDexome sequencingFISHgonad biopsymosaicismXYY syndrome

Identifiers

PMID33912214
PMCPMC8072476
OpenAlexW3155091297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.