Evidence map›Paper›PMID 33912179›Full record

Observational studyFrontiers in immunology2021

Carbamazepine Induces Focused T Cell Responses in Resolved Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Cases But Does Not Perturb the Immunopeptidome for T Cell Recognition.

Nicole A Mifsud, Patricia T Illing, Jeffrey W Lai, Heidi Fettke, Luca Hensen, Ziyi Huang, Jamie Rossjohn, Julian P Vivian, Patrick Kwan, Anthony W Purcell

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Iranian journal of biotechnology · 2024
    Article
  8. Article
  9. Article
  10. Characterization of Drug-Specific CD4Chemical research in toxicology · 2023
    Article
  11. TCR_Explore: A novel webtool for T cell receptor repertoire analysis.Computational and structural biotechnology journal · 2023
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Nicole A MifsudInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Patricia T IllingInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Jeffrey W LaiInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Heidi FettkeInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Luca HensenDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia.
Ziyi HuangInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Jamie RossjohnInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Julian P VivianInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Patrick KwanDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, VIC, Australia.
Anthony W PurcellInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Australian Regenerative Medicine Institute · AUMonash University · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antiseizure medications (ASMs) are frequently implicated in T cell-mediated drug hypersensitivity reactions and cause skin tropic pathologies that range in severity from mild rashes to life-threatening systemic syndromes. During the acute stages of the more severe manifestations of these reactions, drug responsive proinflammatory CD8

Indexed as

AnticonvulsantsCarbamazepineCase-Control StudiesCD8-Positive T-LymphocytesCell Line, TumorClonal Selection, Antigen-MediatedFemaleHealthy VolunteersHLA-B15 AntigenHumansImmunologic MemoryMalePeptidesPrimary Cell CultureProteomicsReceptors, Antigen, T-CellAnticonvulsantsCarbamazepineHLA-B*15:02 antigenHLA-B15 AntigenPeptidesReceptors, Antigen, T-Cellcarbamazepinedrug hypersensitivityimmunopeptidomicsSJSStevens-Johnson syndromeT cell receptorT cells

Identifiers

PMID33912179
PMCPMC8071863
OpenAlexW3153795258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.