ArticleFrontiers in physiology2021
Contrasting Measures of Cerebrovascular Reactivity Between MRI and Doppler: A Cross-Sectional Study of Younger and Older Healthy Individuals.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Cerebrovascular Reactivity and Neurovascular Coupling in Multiple Sclerosis-A Systematic Review.Frontiers in neurology · 2022Pooled it
- Association between cardiorespiratory fitness and cerebrovascular reactivity to a breath-hold stimulus in older adults: influence of aerobic exercise training.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Cerebrovascular reactivity delay measured by blood oxygen level dependent magnetic resonance imaging and gas challenges: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Cerebrovascular reactivity in migraine: a breath-hold BOLD fMRI study.The journal of headache and pain · 2026Observational
- Detection of regional disparity in cerebrovascular reactivity using a custom whole brain functional near-infrared spectroscopy based mapping system: A prospective observational study.PLOS digital health · 2026Article
- Transcranial Doppler ultrasound validation of BOLD-fMRI cerebral blood flow relationship.Magnetic resonance in medicine · 2026Article
- Neurovascular coupling and cerebrovascular reactivity: physiology, lifespan development, pathophysiology, and clinical relevance.Frontiers in physiology · 2026Review
- Article
- Measuring cerebrovascular reactivity in a hemodialysis cohort.Cerebral circulation - cognition and behavior · 2025Article
- The influence of cardiovascular fitness and ventilatory efficiency on fMRI assessed cerebrovascular reactivity in older adults.Frontiers in physiology · 2025Article
- Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury.Brain communications · 2025Review
- Problems and solutions in quantifying cerebrovascular reactivity using BOLD-MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Characterising cerebrovascular reactivity and the pupillary light response-a comparative study.Frontiers in physiology · 2024Article
- Cerebrovascular Reactivity Following Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2024Article
- Cerebral hemodynamics comparison using transcranial doppler ultrasound and 4D flow MRI.Frontiers in physiology · 2023Article
- The relationships between age, sex, and cerebrovascular reactivity to hypercapnia using traditional and kinetic-based analyses in healthy adults.American journal of physiology. Heart and circulatory physiology · 2022Article
- Getting Fit to Counteract Cognitive Aging: Evidence and Future Directions.Physiology (Bethesda, Md.) · 2022Review
- Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: Comparison in younger and older adults.Brain and behavior · 2021Article
- Cerebral Vasoreactivity Changes Over Time in Patients With Different Clinical Manifestations of Cerebral Small Vessel Disease.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebrovascular reactivity (CVR) is used as an outcome measure of brain health. Traditionally, lower CVR is associated with ageing, poor fitness and brain-related conditions (e.g. stroke, dementia). Indeed, CVR is suggested as a biomarker for disease risk. However, recent findings report conflicting associations between ageing or fitness and CVR measures. Inconsistent findings may relate to different neuroimaging modalities used, which include transcranial Doppler (TCD) and blood-oxygen-level-dependant (BOLD) contrast magnetic resonance imaging (MRI). We assessed the relationship between CVR metrics derived from two common imaging modalities, TCD and BOLD MRI, within the same individuals and with expected significant differences (i.e., younger vs. older) to maximise the expected spread in measures. We conducted two serial studies using TCD- and MRI-derived measures of CVR (via inspired 5% CO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.