ArticleFrontiers in neuroscience2021
Engaging Spinal Networks to Mitigate Supraspinal Dysfunction After CP.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Linking corticospinal tract activation and upper-limb motor control in adults with cerebral palsy.Developmental medicine and child neurology · 2024Article
- Spinal cord H-reflex post-activation depression is linked with hand motor control in adults with cerebral palsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Transcutaneous Spinal Stimulation From Adults to Children: A Review.Topics in spinal cord injury rehabilitation · 2023Review
- sPinal cOrd neUromodulatioN to treat Cerebral palsy in pEdiatrics: POUNCE Multisite Randomized Clinical Trial.Frontiers in neuroscience · 2023Article
- Combining spinal neuromodulation and activity based neurorehabilitation therapy improves sensorimotor function in cerebral palsy.Frontiers in rehabilitation sciences · 2023Article
- A pilot study combining noninvasive spinal neuromodulation and activity-based neurorehabilitation therapy in children with cerebral palsy.Nature communications · 2022Article
- Control of structural redundancy from the head to trunk in the human upright standing revealed using a data-driven approach.Scientific reports · 2022Article
- Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder.Bioelectronic medicine · 2022Article
- Reduced wrist flexor H-reflex excitability is linked with increased wrist proprioceptive error in adults with cerebral palsy.Frontiers in neurology · 2022Article
- The Effect of Non-invasive Spinal Cord Stimulation on Anorectal Function in Individuals With Spinal Cord Injury: A Case Series.Frontiers in neuroscience · 2022Article
- An epidural stimulating interface unveils the intrinsic modulation of electrically motor evoked potentials in behaving rats.Journal of neurophysiology · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although children with cerebral palsy seem to have the neural networks necessary to generate most movements, they are markedly dysfunctional, largely attributable to abnormal patterns of muscle activation, often characterized as spasticity, largely reflecting a functionally abnormal spinal-supraspinal connectivity. While it is generally assumed that the etiologies of the disruptive functions associated with cerebral palsy can be attributed primarily to supraspinal networks, we propose that the more normal connectivity that persists between peripheral proprioception-cutaneous input to the spinal networks can be used to guide the reorganization of a more normal spinal-supraspinal connectivity. The level of plasticity necessary to achieve the required reorganization within and among different neural networks can be achieved with a combination of spinal neuromodulation and specific activity-dependent mechanisms. By engaging these two concepts, we hypothesize that bidirectional reorganization of proprioception-spinal cord-brain connectivity to higher levels of functionality can be achieved without invasive surgery.
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