Evidence map›Paper›PMID 33911981›Full record

ReviewContemporary oncology (Poznan, Poland)2021

Epidemiology of lung cancer.

Krishna Chaitanya Thandra, Adam Barsouk, Kalyan Saginala, John Sukumar Aluru, Alexander Barsouk

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Contemporary oncology (Poznan, Poland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06473870 (Understanding Lung Cancer Related Risk Factors and Their Impact), which is not on this map. Cited by 509 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
509citing papers in PubMed, 6 pooled it
77.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06473870 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Understanding Lung Cancer Related Risk Factors and Their Impact

Typeobservational_patient_registrySponsorBiobizkaia Health Research InstituteRan2024 to 2027Enrolled6,160ConditionsLung Cancer Screening
3 · Its place in the literature

Who cites it

509 citing papers in PubMed, 6 syntheses or guidelines pooled it, 819 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Lung Cancer Screening Participation Among Indigenous Peoples Worldwide: A Systematic Review of Challenges and Opportunities.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2025
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Virtual screening and experimental validation of a METTL3-targeting peptide withJournal of enzyme inhibition and medicinal chemistry · 2026
    Article
  8. Article
  9. Observational
  10. Review
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  12. Review
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  20. Review

449 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Krishna Chaitanya ThandraDepartment of Pulmonary and Critical Care Medicine, Sentara Virginia Beach General Hospital, Virginia Beach, VA, USA.
Adam BarsoukHillman Cancer Center, University of Pittsburgh, PA, USA.
Kalyan SaginalaPlains Regional Medical Group Internal Medicine, Clovis, NM, USA.
John Sukumar AluruBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Alexander BarsoukHematologist-Oncologist, Allegheny Health Network, Pittsburgh, PA, USA.
Allegheny Health Network · USHarvard University · USSentara Virginia Beach General Hospital · USUPMC Hillman Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is the leading cause of global cancer incidence and mortality, accounting for an estimated 2 million diagnoses and 1.8 million deaths. Neoplasms of the lungs are the second most common cancer diagnosis in men and women (after prostate and breast cancer, respectively). With increasing access to tobacco and industrialization in developing nations, lung cancer incidence is rising globally. The average age of diagnosis is 70 years old. Men are twice as likely to be diagnosed with lung cancer, which largely reflects differences in tobacco consumption, although women may be more susceptible due to higher proportions of epidermal growth factor receptor mutations and the effects of oestrogen. African American men in the US are at the highest risk of lung cancer. Family history increases risk by 1.7-fold, with a greater risk among first-degree relatives. Tobacco smoking is the greatest preventable cause of death worldwide, accounting for up to 90% of lung cancer cases, and continued consumption is projected to increase global cancer incidence, particularly in developing nations such as China, Russia, and India. Second-hand smoke among children and spouses has likewise been implicated. Radon from natural underground uranium decay is the second leading cause of lung cancer in the developed world. Occupational hazards such as asbestos and environmental exposures such as air pollution, arsenic, and HIV and Tb infection have all been implicated in lung carcinogenesis, while cannabis smoking, electronic cigarettes, heated tobacco products, and COVID-19 have been hypothesized to increase risk.

Indexed as

aetiologyepidemiologyincidencelung cancermortalityrisk factorssurvivaltrends

Identifiers

PMID33911981
PMCPMC8063897
OpenAlexW3132705981

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.