Evidence map›Paper›PMID 33911977›Full record

ArticleContemporary oncology (Poznan, Poland)2021

Contrast-enhanced spectral mammography without and with a delayed image for diagnosing malignancy among mass lesions in dense breast.

Akmaral Serikovna Ainakulova, Zhamilya Zholdybay Zholdybay, Dilyara Radikovna Kaidarova, Natalya Igorevna Inozemtceva, Madina Orazaykyzy Gabdullina, Zhanar Kabdualievna Zhakenova, Alexandra Sergeevna Panina, Dias Kairatovich Toleshbayev, Jandos Mukhtarovich Amankulov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary oncology (Poznan, Poland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Contrast-enhanced mammography improves patient access to functional breast imaging.Journal of medical imaging and radiation oncology · 2025
    Review
  4. Contrast-enhanced mammography in high-dense breasts: a narrative review.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Akmaral Serikovna AinakulovaAsfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Zhamilya Zholdybay ZholdybayAsfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Dilyara Radikovna KaidarovaAsfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Natalya Igorevna InozemtcevaKazakh Institute of Oncology and Radiology, Almaty, Kazakhstan.
Madina Orazaykyzy GabdullinaAsfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Zhanar Kabdualievna ZhakenovaAsfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Alexandra Sergeevna PaninaAsfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Dias Kairatovich ToleshbayevAsfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Jandos Mukhtarovich AmankulovAsfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Kazakh National Medical University · KZKazakh Institute of Oncology and Radiology · KZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim of the studyTo analyse the diagnostic performance of contrast-enhanced spectral mammography (CESM) based on morphologic and enhancement patterns of mass lesions in dense breast using different protocols: CESM without delayed image and CESM with delayed image. MATERIAL AND

methodsA total of 151 informed women with suspicious for malignancy mass lesions in dense breast were included in this study. All of them underwent CESM using 2 protocols. A total of 155 lesions were pathomorphologically verified. We analysed morphologic patterns on low-energy (LE) images and recombined images (RI) by defining the shape, margin, and dynamic patterns based on delayed images.

resultsThe comparative analysis revealed that the shape and margins on RI were more significant than those on LE images. The dynamic indicators of CESM were found to be highly significant in dense breasts. The correlation between kinetic curve and histological results demonstrated that a persistent type of curve was common for benign lesions, accounting for 15/22 (68.1%); plateau and washout - for malignant lesions, accounting for 24/89 (26.9%) and 61/89 (68.5%), respectively. Delayed image leads to an increase of specificity up to 12.4%, which is statistically significant. The area under the curve (AUC) in CESM with delayed image is larger than that in CESM without delayed image (

conclusionsCESM is sensitive for the differential diagnosis of breast lesions. CESM with delayed image has higher specificity than CESM without delayed image. Delayed images with plateau and washout are typical for malignancy.

Indexed as

breast cancerbreast lesionscontrast-enhanced spectral mammographydense breast

Identifiers

PMID33911977
PMCPMC8063896
OpenAlexW3159868323

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.