ArticleAnnals of dermatology2020
Particulate Matters Induce Apoptosis in Human Hair Follicular Keratinocytes.
Article in Annals of dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed.
- Hair Growth-Supporting and Follicle-Protective Potential of a Botanical-Based Supplement Ingredient: In Vitro, Ex Vivo, and Molecular Docking Studies.Biomolecules · 2026Article
- Long-term particulate matter exposure and risk of androgenetic alopecia: A nationwide cohort study.JAAD international · 2026Article
- From crown to cosmetics: Exploring the efficacy of an upcycled pineapple biopolymer in sustainable skincare, suncare and hair care applications.International journal of cosmetic science · 2026Article
- [Effects of particulate matter pollution on human skin].Dermatologie (Heidelberg, Germany) · 2026Review
- Particulate matter exposure induces maternal scalp hair loss after birth in C57/B6 mouse via alteration of inflammatory and apoptotic pathways.Frontiers in endocrinology · 2026Article
- Metabolomic Reprogramming Induced by Benzo[a]pyene in Skin Keratinocytes and Protective Effects of Glutathione Amino Acid Precursors.Journal of cosmetic dermatology · 2025Article
- Air Pollution and Skin Diseases.Annals of dermatology · 2025Review
- The Effects of Environmental Pollutants and Exposures on Hair Follicle Pathophysiology.Skin appendage disorders · 2024Review
- Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets.Molecules (Basel, Switzerland) · 2024Review
- Environmental Air Pollutants Affecting Skin Functions with Systemic Implications.International journal of molecular sciences · 2023Review
- Particulate matter 10 induces oxidative stress and apoptosis in rhesus macaques skin fibroblast.PeerJ · 2023Article
- Effects of <10-µm Particulate Matter on Cultured Human Sebocytes and Outer Root Sheath Cells and Usefulness of Siegesbeckia Herba Extract.Annals of dermatology · 2022Article
- Preventative effects of antioxidants on changes in sebocytes, outer root sheath cells, andInternational journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParticulate matters (PM) comprise a heterogeneous mixture of particles suspended in air. A recent study found that urban PMs may penetrate into hair follicles via transfollicular and transdermal routes in dorsal skin.
objectiveTo investigate the effects of PM on
methodsTUNEL staining was employed to check cells undergoing apoptosis in cultured hair follicles after PM treatment. MTT assay was employed to check cell viability after PM treatment. Quantitative real-time PCR analysis was employed to quantitate the expression of inflammatory genes, matrix metalloproteinases (MMPs), and Duox1. Inflammatory cytokine levels were measured by ELISA after PM treatment. The level of reactive oxygen species (ROS) production was measured using a chemical fluorescent probe by a fluorescence plate reader.
resultsAbundant TUNEL-positive cells were observed in the keratinocyte region of hair including the epidermis, sebaceous gland, outer root sheath (ORS), inner root sheath (IRS), and bulb region. The viability of follicular cells, including the ORS, was found to be decreased upon PM exposure. mRNA expression and protein levels of inflammatory response genes and MMPs were upregulated in a dose-dependent manner by PM treatment. ROS levels were also increased by PM.
conclusionThese data strongly suggest that penetrated PMs from air pollution may cause apoptotic cell death to follicular keratinocytes by increased production of ROS and inflammatory cytokines, which could impair hair growth.
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