Evidence map›Paper›PMID 33911705›Full record

ArticleAnnals of dermatology2020

Minocycline and Its Impact on Microbial Dysbiosis in the Skin and Gastrointestinal Tract of Acne Patients.

Katherine G Thompson, Barbara M Rainer, Corina Antonescu, Liliana Florea, Emmanuel F Mongodin, Sewon Kang, Anna L Chien

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Katherine G ThompsonDepartment of Dermatology, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-3532-0779
Barbara M RainerDepartment of Dermatology, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-8643-7507
Corina AntonescuInstitute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-9151-1217
Liliana FloreaInstitute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-8124-2324
Emmanuel F MongodinInstitute for Genome Sciences, University of Maryland, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-3833-7437
Sewon KangDepartment of Dermatology, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-7841-9392
Anna L ChienDepartment of Dermatology, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-6492-3080
Johns Hopkins University · USUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssociations between acne and gastrointestinal comorbidities suggest that microbial dysbiosis and intestinal permeability may promote inflammatory acne, a condition often managed with oral antibiotics.

objectiveWe performed a case-control study to investigate the skin and gut microbiota in 8 acne patients before and after receiving oral minocycline compared to controls matched by age ±5 years, sex, and race.

methodsDNA was extracted from stool samples and facial skin swabs. Sequencing of the V3V4 region of the bacterial 16S rRNA gene was performed using Illumina MiSeq and analyzed using QIIME/MetaStats 2.0 software.

resultsAcne patients included 7 female and 1 male, ages 20~32. Shannon diversity was not significantly different between the skin (

conclusionMinocycline produces significant derangements in the microbiota of the skin and gut, including many probiotic species, highlighting the potential for more targeted antimicrobial treatments for acne.

Indexed as

Acne vulgarisBacteroidetesFirmicutesMicrobiomeMinocyclinePropionibacterium

Identifiers

PMID33911705
PMCPMC7992645
OpenAlexW3000384045

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.