Evidence map›Paper›PMID 33911622›Full record

ArticleAnnals of dermatology2019

Successful Treatment of Genital Warts with Ingenol Mebutate Monitored with Optical Coherence Tomography and Reflectance Confocal Microscopy.

Markus Reinholz, Benjamin M Clanner-Engelshofen, Markus V Heppt, Yoji Hirai, Thomas Ruzicka, Carola Berking, Tanja von Braunmühl

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Markus ReinholzDepartment of Dermatology and Allergy, University Hospital of Munich (LMU), Munich, Germany.ORCID https://orcid.org/0000-0002-0465-3506
Benjamin M Clanner-EngelshofenDepartment of Dermatology and Allergy, University Hospital of Munich (LMU), Munich, Germany.ORCID https://orcid.org/0000-0001-9863-3380
Markus V HepptDepartment of Dermatology and Allergy, University Hospital of Munich (LMU), Munich, Germany.ORCID https://orcid.org/0000-0003-4603-1825
Yoji HiraiDepartment of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kawasaki Medical School, Okayama, Japan.ORCID https://orcid.org/0000-0003-2201-6129
Thomas RuzickaDepartment of Dermatology and Allergy, University Hospital of Munich (LMU), Munich, Germany.ORCID https://orcid.org/0000-0002-9596-1749
Carola BerkingDepartment of Dermatology and Allergy, University Hospital of Munich (LMU), Munich, Germany.ORCID https://orcid.org/0000-0003-0229-8931
Tanja von BraunmühlDepartment of Dermatology and Allergy, University Hospital of Munich (LMU), Munich, Germany.ORCID https://orcid.org/0000-0002-4510-7616
LMU Klinikum · DEOkayama University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ingenol mebutate (IM) is approved for the treatment of actinic keratosis and induces cell death in precancerous lesions. The efficacy of IM in the treatment of genital warts was investigated in a therapy-refractory patient. The 74-year-old male was treated with IM gel for three consecutive days. Treatment course and efficacy were evaluated by clinical inspection and non-invasive diagnostics namely optical coherence tomography (OCT) and reflectance confocal microscopy (RCM). Within 24 to 48 hours IM induced a strong local inflammatory reaction. One week later a complete response was observed. OCT and RCM showed a strong reaction after treatment with erosions, swelling of cells, and a subepidermal dark band in representative lesions. IM has the advantage of a short treatment period in contrast to other topical treatments and shows a promising clinical outcome. Larger studies are needed to validate the data.

Indexed as

Condylomata acuminataconfocalMicroscopyNeoplasmsOptical coherence tomography

Identifiers

PMID33911622
PMCPMC7992764
OpenAlexW2957802631

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.