ArticleAnnals of dermatology2018
Citron Essential Oils Alleviate the Mediators Related to Rosacea Pathophysiology in Epidermal Keratinocytes.
Article in Annals of dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Recent Advances in the Management of Rosacea through Natural Compounds.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Rosacea: Practical Guidance and Challenges for Clinical Management.Clinical, cosmetic and investigational dermatology · 2024Review
- Effect of COVID-19 and Face Masks on the Condition of Rosacea - A Retrospective Analysis of 87 Patients.Clinical, cosmetic and investigational dermatology · 2023Article
- The Effect of Capsaicin on Neuroinflammatory Mediators of Rosacea.Annals of dermatology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCitron is well known for an abundance of antioxidative and anti-inflammatory ingredients such as vitamin C, polyphenol compounds, flavonoids, and limonoids.
objectiveIn this study, we aimed to evaluate the effects of citron essential oils on rosacea mediators in activated keratinocytes
methodsNormal human epidermal keratinocytes (NHEKs) were stimulated with 1α, 25-dihydroxyvitamin D
resultsThe messenger RNA (mRNA) and protein levels of KLK5 and LL-37 induced by VD
conclusionThese results show that citron essential oils have suppressive effects on rosacea mediators in activated epidermal keratinocytes, which indicates that the citron essential oils may be valuable adjuvant therapeutic agents for rosacea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.