Evidence map›Paper›PMID 33911469›Full record

ArticleWorld journal of gastroenterology2021

Apolipoprotein E variants correlate with the clinical presentation of paediatric inflammatory bowel disease: A cross-sectional study.

Aleksandra Glapa-Nowak, Mariusz Szczepanik, Barbara Iwańczak, Jarosław Kwiecień, Anna Barbara Szaflarska-Popławska, Urszula Grzybowska-Chlebowczyk, Marcin Osiecki, Marcin Dziekiewicz, Andrzej Stawarski, Jarosław Kierkuś and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Aleksandra Glapa-NowakDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, Poznań 60-572, Poland.
Mariusz SzczepanikDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, Poznań 60-572, Poland.
Barbara IwańczakDepartment of Pediatrics, Medical University of Wroclaw, Wroclaw 50-369, Poland.
Jarosław KwiecieńDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Zabrze 41-800, Poland.
Anna Barbara Szaflarska-Popławska
Urszula Grzybowska-ChlebowczykDepartment of Pediatrics, Faculty of Medical Sciences, Medical University of Silesia in Katowice, Katowice 40-752, Poland.
Marcin OsieckiDepartment of Gastroenterology, Hepatology, Feeding Disorders and Paediatrics, The Children's Memorial Health Institute, Warsaw 04-730, Poland.
Marcin DziekiewiczDepartment of Pediatric Gastroenterology and Nutrition, Medical University of Warsaw, Warsaw 02-091, Poland.
Andrzej StawarskiDepartment and Clinic of Pediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Wroclaw 50-369, Poland.
Jarosław KierkuśDepartment of Gastroenterology, Hepatology, Feeding Disorders and Paediatrics, The Children's Memorial Health Institute, Warsaw 04-730, Poland.
Tomasz BanasiewiczChair and Department of General Surgery, Gastroenterological Surgical Oncology and Plastic Surgery, Poznań University of Medical Sciences, Poznań 60-355, Poland.
Aleksandra BanaszkiewiczDepartment of Pediatric Gastroenterology and Nutrition, Medical University of Warsaw, Warsaw 02-091, Poland.
Jarosław WalkowiakDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, Poznań 60-572, Poland. jarwalk@ump.edu.pl.
Poznan University of Medical Sciences · PLChildren's Memorial Health Institute · PLMedical University of Silesia · PLMedical University of Warsaw · PLWroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt has been suggested that apolipoprotein E (

aimTo summarise that APOE polymorphisms are associated with the risk of developing IBD and the early age of disease onset.

methodsIn total, 406 patients aged 3-18 with IBD (192 had ulcerative colitis and 214 had Crohn's disease) were genotyped using the TaqMan hydrolysis probe assay. Clinical expression was described at diagnosis and the worst flare by disease activity scales, albumin and C-reactive protein levels, localisation and behaviour (Paris classification). Systemic steroid intake with the total number of courses, immunosuppressive, biological, and surgical treatment with the time and age of the first intervention were determined. The total number of exacerbation-caused hospitalisations, the number of days spent in hospital due to exacerbation, the number of relapses, and severe relapses were also estimated.

resultsUlcerative colitis patients with the

conclusion

Indexed as

Colitis, UlcerativeCrohn DiseaseInflammatory Bowel DiseasesAdolescentApolipoproteins EChildChild, PreschoolCross-Sectional StudiesHumansApolipoproteins EApolipoprotein E polymorphismCrohn’s diseaseDisease severityImmunosuppressionSurgeryUlcerative colitis

Identifiers

PMID33911469
PMCPMC8047531
OpenAlexW3156846412

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.