Evidence map›Paper›PMID 33911448›Full record

ArticleJournal of global infectious diseases

Maternal and Perinatal Outcomes of Influenza in Pregnancy after Treatment with Oseltamivir.

Kavitha Abraham, Anuja Abraham, Annie Regi, Jessie Lionel, Elsy Thomas, Reeta Vijayaselvi, L Jeyaseelan, Asha Mary Abraham, Sridhar Santhanam, Kurian Anil Kuruvilla and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of global infectious diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Kavitha AbrahamDepartment of Obstetrics and Gynaecology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Anuja AbrahamDepartment of Obstetrics and Gynaecology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Annie RegiDepartment of Obstetrics and Gynaecology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Jessie LionelDepartment of Obstetrics and Gynaecology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Elsy ThomasDepartment of Obstetrics and Gynaecology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Reeta VijayaselviDepartment of Obstetrics and Gynaecology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
L JeyaseelanDepartment of Biostatistics, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Asha Mary AbrahamDepartment of Virology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Sridhar SanthanamDepartment of Neonatology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Kurian Anil KuruvillaDepartment of Neonatology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Mark C SteinhoffGlobal Health Center, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Christian Medical College & Hospital · INChristian Medical College · INCincinnati Children's Hospital Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextInfluenza infection in pregnancy causes 4%-8% case fatality and five times more perinatal mortality. Influenza is a major contributor to mortality in developing countries; however, the morbidity has largely been underestimated. Public health interventions for prevention are also lacking.

aimsThis study aimed to determine the seasonality of influenza in pregnant Indian women and to estimate the maternal and perinatal morbidity after treatment with oseltamivir. SETTINGS AND

designThis was a prospective observational cohort study, conducted in a tertiary hospital. SUBJECTS AND

methodsPregnant women with ILI (influenza-like illness) were recruited into Cohort 1 (polymerase chain reaction [PCR] positive) and Cohort 2 (PCR negative). Gestational age-matched asymptomatic controls formed Cohort 3. Women in Cohort 1 received oseltamivir for 5 days. The incidence of small-for-gestational age (SGA) and preterm birth were the primary outcomes. Maternal and neonatal morbidity formed the secondary outcomes. STATISTICAL ANALYSIS: Unmatched (Cohort 1 and 2) and matched analysis (Cohort 1 and 3) were done. Student's

resultsYear-round incidence of influenza was recorded. Severe illness was more in Cohort 1 compared to Cohort 2 (36.2% vs. 6.3%;

conclusionInfluenza in pregnancy showed year-round incidence and increased maternal and neonatal morbidity despite treatment with oseltamivir. We suggest the need for newer interventions to curtail the illness in pregnancy.

Indexed as

Influenzainfluenza like illnesspregnancypreterm birthsmall for gestational age

Identifiers

PMID33911448
PMCPMC8054794
OpenAlexW3128388140

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.