ArticleNature2021
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07680660 (A Multicenter Randomized Controlled Trial on the Efficacy and Safety of Cervical Lymph Vessel/Node-venous Anastomosis Combined With Donepezil Versus Donepezil Alone in the Treatment of Alzheimer's Disease), which is not on this map. Cited by 284 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
284citing papers in PubMed, 2 pooled it
29.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter Randomized Controlled Trial on the Efficacy and Safety of Cervical Lymph Vessel/Node-venous Anastomosis Combined With Donepezil Versus Donepezil Alone in the Treatment of Alzheimer's Disease
Who cites it
284 citing papers in PubMed, 2 syntheses or guidelines pooled it, 385 citations in OpenAlex.
- Therapeutic Modulation of Meningeal Lymphatics: A Systematic Review of Preclinical Evidence Across Neurological Disorders.Cellular and molecular neurobiology · 2025Pooled it
- Role of meningeal lymphatic vessels in brain homeostasis.Frontiers in immunology · 2025Pooled it
- Chrysanthemum Morifolium-Derived Nanovesicles Reduce Lactate-Associated Histone Lactylation and Modulate Microglia-Mediated Neuroinflammation in Sepsis-Associated Encephalopathy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The glymphatic-lymphatic axis: known pathways, open questions, and emerging roles in neurodegeneration.Translational neurodegeneration · 2026Review
- AI-based characterization of Alzheimer's disease phenotypes from population-scale single-cell data.Nature medicine · 2026Article
- Review
- The Glymphatic System in Neurological Diseases: Mechanisms, Imaging Surrogates, and Translational Uncertainties.Current neurology and neuroscience reports · 2026Review
- Border-Associated Macrophage Migrasomes in Alzheimer's Disease: An Emerging Aβ-Senescence-Microglia Axis?Cells · 2026Review
- Novel Therapeutic Insights Into Alzheimer's Disease: Glymphatic System and Meningeal Lymphatic Vessels.Aging cell · 2026Review
- Article
- Mapping Lymphatic Drainage from the Human Brain to the Head and Neck: Potential Surgical Implications for Dementia.Archives of plastic surgery · 2026Article
- Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases.Translational neurodegeneration · 2026Review
- Review
- Article
- Caspase-1-mediated pyroptosis drives secondary thalamic neurodegeneration after focal cerebral infarction.Molecular biology reports · 2026Article
- The role of Annexin A2 in Alzheimer's disease: From cellular functions to therapeutic potential.The FEBS journal · 2026Review
- Neuroinflammation in Alzheimer's and Parkinson's diseases: pathogenic mechanisms and therapeutic strategies.Translational neurodegeneration · 2026Review
- Article
- The Clearance-Centered Bottleneck in Alzheimer's Disease: From Coupled Glymphatic-Lymphatic Circuits to Therapeutic Opportunities.Molecular neurobiology · 2026Review
224 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 6 institutions in 1 country.
Sandro Da MesquitaDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA. damesquita@mayo.edu.ORCID http://orcid.org/0000-0002-0786-5010
Zachary Papadopoulos *Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO, USA.
Taitea Dykstra *Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-7756-809X
Logan Brase *Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-7175-3208
Fabiana Geraldo FariasDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-5215-7304
Morgan WallDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Hong JiangDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Chinnappa Dilip KodiraPureTech Health, Boston, MA, USA.
Kalil Alves de LimaCenter for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-9149-168X
Jasmin HerzCenter for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-6325-863X
Antoine LouveauDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Dylan H GoldmanDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Andrea Francesca SalvadorDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-9197-7575
Suna Onengut-GumuscuCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Emily FarberCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Nisha DabhiDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Tatiana KennedyDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Mary Grace MilamDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Wendy BakerDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Igor SmirnovDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-3872-7793
Dominantly Inherited Alzheimer Network
Bruno A BenitezDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-2699-3878
Celeste M KarchDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-6854-5547
Richard J PerrinDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-3443-7716
Martin FarlowIndiana School of Medicine, Indianapolis, IN, USA.
Jasmeer P ChhatwalMassachusetts General Hospital, Harvard Medical School, Department of Neurology, Boston, MA, USA.
David M HoltzmanDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Carlos CruchagaDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
Oscar HarariDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-2635-6975
Jonathan KipnisDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA. kipnis@wustl.edu.ORCID http://orcid.org/0000-0002-3714-517X
Washington University in St. Louis · USUniversity of Virginia · USHarvard University · USCleveland Clinic Lerner College of Medicine · USJacksonville College · USPureTech (United States) · US
Funding
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5MImaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9MWASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5MResearch Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7MDominantly Inherited Alzheimer NetworkUF1AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2014 to 2017
$21.6MImaging CoreU01AG032438 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2008 to 2009
$6.1MMENDELIAN RANDOMIZATION FOR UNBIAS BIOMARKER DISCOVERY FOR AD AND OTHER COMPLEX TRAITSR01AG057777 · NIA · WASHINGTON UNIVERSITY · PI HARARI, OSCAR · 2018 to 2022
$4.1MUSING QUANTITATIVE TRAITS TO IDENTIFY NOVEL GENES FOR ALZHEIMERS DISEASE AND OTHER COMPLEX TRAITSRF1AG053303 · NIA · WASHINGTON UNIVERSITY · PI CLIMER, SHARLEE, CRUCHAGA, CARLOS · 2016 to 2020
$4.0MMeninges-to-astrocyte communication in cognitive functionR01AG034113 · NIA · UNIVERSITY OF VIRGINIA · PI KIPNIS, JONATHAN · 2010 to 2019
$3.8MImmune system supports brain functionR37AG034113 · NIA · WASHINGTON UNIVERSITY · PI Jonathan Kipnis · 2020 to 2026
$3.7MIdentifying Rare Variants that Increase Risk for Alzheimer's DiseaseRF1AG044546 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS · 2019 to 2019
$3.6MNIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS P50 AG005681NIA NIH HHS R01 AG034113NIA NIH HHS R01 AG057777NIA NIH HHS R01 AG062734NIA NIH HHS R37 AG034113NIA NIH HHS R56 AG067764NIA NIH HHS RF1 AG044546NIA NIH HHS RF1 AG053303NIA NIH HHS RF1 AG057496NIA NIH HHS RF1 AG058501NIA NIH HHS U01 AG032438NIA NIH HHS U19 AG032438NIA NIH HHS UF1 AG032438NIH HHS AG034113NIH HHS AG057496NINDS NIH HHS R01 NS118146
Abstract
Alzheimer's disease (AD) is the most prevalent cause of dementia
Indexed as
ImmunotherapyAgingAlzheimer DiseaseAmyloid beta-PeptidesAnimalsAntibodies, Monoclonal, HumanizedBrainDisease Models, AnimalHippocampusHumansInflammationLymphatic VesselsMaleMeningesMiceMicrogliaaducanumabAmyloid beta-PeptidesAntibodies, Monoclonal, HumanizedVascular Endothelial Growth Factor C
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT07680660ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.