ArticleNature2021
Somatic mutation landscapes at single-molecule resolution.
Abstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 322 papers.
0numbers the graph read from it
0cells of the map it votes in
322citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
322 citing papers in PubMed.
- Comprehensive Genomic Analysis of Normal and Cancer Cells Elucidates the Elevated Mutational Burden in Cancer.Cancer research · 2026Article
- Cancer treatment alters mutant selection in normal esophagus.Nature genetics · 2026Article
- Somatic mosaicism in the brain: linking development, ageing and neurodegeneration.Nature reviews. Neurology · 2026Review
- A guide to understanding tumour evolution through the lens of population genetics.Nature reviews. Cancer · 2026Review
- Article
- Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026Review
- The Evolution of Polyclonal Competition in Aging Hematopoiesis.Cancer discovery · 2026Article
- Motif-centered analyses reveal universal and tissue-specific mutagenic mechanisms operating in the human body.NAR cancer · 2026Article
- Methyltransferase-assisted single duplex sequencing for detecting circulating tumor DNA.EMBO molecular medicine · 2026Article
- Article
- Stem cells as an essential mediator of the exercise-tumorigenesis link.Nature reviews. Cancer · 2026Review
- Somatic mutations and genome mosaicism in aging and disease.Experimental & molecular medicine · 2026Review
- Article
- Article
- BASELINE: a CRISPR base editing platform for mammalian-scale single-cell lineage tracing.Nucleic acids research · 2026Article
- High-fidelity rare structural variant detection with HiFiRE3 reduced representation via restriction enzyme ends.bioRxiv : the preprint server for biology · 2026Article
- Enrichment of mutated DNA enables ultra-sensitive ctDNA detection in NSCLC using shallow targeted sequencing.Scientific reports · 2026Article
- The cumulative impact of passenger mutations on cancer development.Nature communications · 2026Article
- Article
- Charting single-cell lineages with synthetic and natural barcodes.Nature reviews. Genetics · 2026Review
262 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
32 authors.
Federico AbascalWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-6201-1587
Luke M R Harvey *Wellcome Sanger Institute, Hinxton, UK.
Emily Mitchell *Wellcome Sanger Institute, Hinxton, UK.
Andrew R J Lawson *Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-3592-1005
Stefanie V Lensing *Wellcome Sanger Institute, Hinxton, UK.
Peter Ellis *Wellcome Sanger Institute, Hinxton, UK.
Andrew J C RussellWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-5411-2807
Raul E AlcantaraWellcome Sanger Institute, Hinxton, UK.
Adrian Baez-OrtegaWellcome Sanger Institute, Hinxton, UK.
Yichen WangWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-5122-7545
Eugene Jing KwaWellcome Sanger Institute, Hinxton, UK.
Henry Lee-SixWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-4831-8088
Alex CaganWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-7857-4771
Tim H H CoorensWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-5826-3554
Michael Spencer ChapmanWellcome Sanger Institute, Hinxton, UK.
Sigurgeir OlafssonWellcome Sanger Institute, Hinxton, UK.
Steven LeonardWellcome Sanger Institute, Hinxton, UK.
David JonesWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-0407-0386
Heather E MachadoWellcome Sanger Institute, Hinxton, UK.
Megan DaviesWellcome-MRC Cambridge Stem Cell Institute, Cambridge Biomedical Campus, Cambridge, UK.
Nina F ØbroWellcome-MRC Cambridge Stem Cell Institute, Cambridge Biomedical Campus, Cambridge, UK.
Krishnaa T MahubaniDepartment of Haematology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-1327-2334
Kieren AllinsonCambridge Brain Bank, Division of the Human Research Tissue Bank, Addenbrooke's Hospital, Cambridge, UK.
Moritz GerstungEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.ORCID http://orcid.org/0000-0001-6709-963X
Kourosh Saeb-ParsyDepartment of Surgery, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0633-3696
David G KentWellcome-MRC Cambridge Stem Cell Institute, Cambridge Biomedical Campus, Cambridge, UK.
Elisa LaurentiWellcome-MRC Cambridge Stem Cell Institute, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-9917-9092
Michael R StrattonWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-6035-153X
Raheleh RahbariWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-1839-7785
Peter J CampbellWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-3921-0510
Robert J OsborneWellcome Sanger Institute, Hinxton, UK. r.osborne@biofidelity.com.ORCID http://orcid.org/0000-0002-1914-1239
Iñigo MartincorenaWellcome Sanger Institute, Hinxton, UK. im3@sanger.ac.uk.ORCID http://orcid.org/0000-0003-1122-4416
Funding
Cancer Research UK 21777Cancer Research UK 27114Medical Research Council MC_PC_17230Wellcome Trust 107630/Z/15/ZWellcome Trust 203151/Z/16/ZWellcome Trust C66259/A27114
Abstract
Somatic mutations drive the development of cancer and may contribute to ageing and other diseases
Indexed as
MutationAlzheimer DiseaseBlood CellsCell DifferentiationCell DivisionCohort StudiesColonDNA Mutational AnalysisEpitheliumGranulocytesHealthy VolunteersHumansMaleMiddle AgedMuscle, SmoothMutagenesis
Identifiers
PMID
33911282What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.