ArticleScientific reports2021
Body weight variability and the risk of cardiovascular outcomes in patients with nonalcoholic fatty liver disease.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Weight variability and cardiovascular outcomes: a systematic review and meta-analysis.Cardiovascular diabetology · 2023Pooled it
- Body weight variability and mortality in older adults: a nationwide population-based cohort study.Scientific reports · 2026Article
- Association of annual percentage changes in anthropometric indices with all-cause mortality: a 14-year longitudinal study of older US adults.Frontiers in public health · 2026Article
- Influence of Weight Loss and Weight Regain on Adipose Tissue Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Impact of Change, Fluctuation, or Variability in Weight on the Risk of Nonalcoholic Fatty Liver Disease in General Population: A Systematic Review and Meta-Analysis.Health science reports · 2025Article
- Association of variabilities in body mass index and metabolic parameters with post-kidney transplantation renal outcomes.Scientific reports · 2024Article
- The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Changes in Macronutrients during Dieting Lead to Weight Cycling and Metabolic Complications in Mouse Model.Nutrients · 2024Article
- Long-Term Outcomes Associated with NAFLD, ASCVD, and All-Cause Mortality of Patients with Metabolic Syndrome.Journal of clinical medicine · 2022Article
- Clinical Differences and Non-Alcoholic Fatty Liver Disease-Related Factors of Lean and Non-Lean Patients with Metabolic Syndrome.Journal of clinical medicine · 2022Article
- Repercussions of absolute and time-rated BMI "yo-yo" fluctuations on cardiovascular stress-related morbidities within the vascular-metabolic CUN cohort.Frontiers in endocrinology · 2022Article
- Metabolic causes and consequences of nonalcoholic fatty liver disease (NAFLD).Metabolism open · 2021Article
- Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease.Nutrients · 2021Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the association between body weight variability and the risks of cardiovascular disease and mortality in patients with nonalcoholic fatty liver disease (NAFLD) using large-scale, nationwide cohort data. We included 726,736 individuals with NAFLD who underwent a health examination between 2009 and 2010. NAFLD was defined as a fatty liver index ≥ 60, after excluding significant alcohol intake, viral hepatitis, and liver cirrhosis. Body weight variability was assessed using four indices, including variability independent of the mean (VIM). During a median 8.1-year follow-up, we documented 11,358, 14,714, and 22,164 cases of myocardial infarction (MI), stroke, and all-cause mortality, respectively. Body weight variability was associated with an increased risk of MI, stroke, and mortality after adjusting for confounding variables. The hazard ratios (HRs) (95% confidence intervals) for the highest quartile, compared with the lowest quartile, of VIM for body weight were 1.15 (1.10-1.20), 1.22 (1.18-1.26), and 1.56 (1.53-1.62) for MI, stroke, and all-cause mortality, respectively. Body weight variability was associated with increased risks of MI, stroke, and all-cause mortality in NAFLD patients. Appropriate interventions to maintain a stable weight could positively affect health outcomes in NAFLD patients.
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