ArticleNature communications2021
Initiation and amplification of SnRK2 activation in abscisic acid signaling.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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Who cites it
120 citing papers in PubMed, 245 citations in OpenAlex.
- TheInternational journal of molecular sciences · 2026Article
- From activation to desensitization: How ABA balances plant growth and abiotic stress response?Plant communications · 2026Review
- Article
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- Ancient Herb, Modern Metabolomics: Primary and Secondary Metabolite Profiling of Wild Fennel (Plants (Basel, Switzerland) · 2026Article
- Genome-Wide Analysis of theInternational journal of molecular sciences · 2026Article
- Evaluating Causal Claims in Plant Developmental Metabolism: A When-Where-How Framework.Plants (Basel, Switzerland) · 2026Review
- Water use efficiency in cereal crops: stomatal, hydraulic, biochemical mechanisms, and translational strategies for improvement.Photosynthesis research · 2026Review
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- A review of ARGOS-mediated regulation of plant organ size: molecular mechanisms, environmental interactions, and agricultural implications.Functional & integrative genomics · 2026Review
- Functional Characterization ofPlants (Basel, Switzerland) · 2026Article
- The MPK6-WRKY49 module links MAPK signaling to ABA biosynthesis and drought tolerance in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- Intermolecular-Interaction-Driven Adaptive Remodeling: A Network Perspective on Plant Abiotic Stress Responses.Plants (Basel, Switzerland) · 2026Review
- SnRK2.6 phosphorylates sucrose transporter ZmSUT1 to enhance yield by modulating leaf senescence in maize.Science advances · 2026Article
- Integrative metabolome and transcriptome of different tree size reveal wood formation in Corymbia citriodora.BMC genomics · 2026Article
- Molecular Mechanisms of Plant Stress Tolerance: From Stress Perception to Phytohormonal Crosstalk and Transcriptional Regulation.Current issues in molecular biology · 2026Review
- Evolutionary-based remodeling of ABA receptors reveals the structural basis of hormone perception and regulation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Functional Analysis ofPlants (Basel, Switzerland) · 2026Article
- Holistic overview of regulatory networks governing seed dormancy and germination in plants.Science China. Life sciences · 2026Review
- Salt-stress-induced tomato sweetening involves an SlSnRK2.6-SlZHD8 sugar accumulation cascade triggered by root-derived abscisic acid.The EMBO journal · 2026Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phytohormone abscisic acid (ABA) is crucial for plant responses to environmental challenges. The SNF1-regulated protein kinase 2s (SnRK2s) are key components in ABA-receptor coupled core signaling, and are rapidly phosphorylated and activated by ABA. Recent studies have suggested that Raf-like protein kinases (RAFs) participate in ABA-triggered SnRK2 activation. In vitro kinase assays also suggest the existence of autophosphorylation of SnRK2s. Thus, how SnRK2 kinases are quickly activated during ABA signaling still needs to be clarified. Here, we show that both B2 and B3 RAFs directly phosphorylate SnRK2.6 in the kinase activation loop. This transphosphorylation by RAFs is essential for SnRK2 activation. The activated SnRK2s then intermolecularly trans-phosphorylate other SnRK2s that are not yet activated to amplify the response. High-order Arabidopsis mutants lacking multiple B2 and B3 RAFs show ABA hyposensitivity. Our findings reveal a unique initiation and amplification mechanism of SnRK2 activation in ABA signaling in higher plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.