ArticleTranslational psychiatry2021
White matter deficits in cocaine use disorder: convergent evidence from in vivo diffusion tensor imaging and ex vivo proteomic analysis.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 27 citations in OpenAlex.
- Global white matter microstructure changes induced by repetitive transcranial magnetic stimulation in cocaine use disorder: a longitudinal correlational tractography study.Brain imaging and behavior · 2026Article
- The mesocorticolimbic system in stimulant use disorder.Molecular psychiatry · 2025Review
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
- Frontal White Matter Changes and Craving Recovery in Inpatients With Heroin Use Disorder.JAMA network open · 2024Article
- Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans: an overview of recent findings.Neural regeneration research · 2024Article
- FRONTAL WHITE MATTER CHANGES INDICATE RECOVERY WITH INPATIENT TREATMENT IN HEROIN ADDICTION.medRxiv : the preprint server for health sciences · 2024Article
- Imaging neuroinflammation in individuals with substance use disorders.The Journal of clinical investigation · 2024Review
- Non-local diffusion-based biomarkers in patients with cocaine use disorder.Neuroimage. Reports · 2024Article
- Cingulate cortical thickness in cocaine use disorder: mediation effect between early life stress and cocaine consumption.Acta neuropsychiatrica · 2024Article
- Chronic Cocaine Use and White Matter Coherence: A Diffusion Tensor Imaging Study.Journal of studies on alcohol and drugs · 2023Article
- A Longitudinal Investigation of Blood Neurofilament Light Chain Levels in Chronic Cocaine Users.Molecular neurobiology · 2023Article
- Cocaine Use May Moderate the Associations of HIV and Female Sex with Neurocognitive Impairment in a Predominantly African American Population Disproportionately Impacted by HIV and Substance Use.AIDS patient care and STDs · 2023Article
- Whole-brain white matter abnormalities in human cocaine and heroin use disorders: association with craving, recency, and cumulative use.Molecular psychiatry · 2023Article
- Prefrontal-habenular microstructural impairments in human cocaine and heroin addiction.Neuron · 2022Article
- Sex differences in brain regional homogeneity during acute abstinence in cocaine use disorder.Addiction biology · 2022Article
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
Abstract
White matter (WM) abnormalities in patients with cocaine use disorder (CUD) have been studied; however, the reported effects on the human brain are heterogenous and most results have been obtained from male participants. In addition, biological data supporting the imaging findings and revealing possible mechanisms underlying the neurotoxic effects of chronic cocaine use (CU) on WM are largely restricted to animal studies. To evaluate the neurotoxic effects of CU in the WM, we performed an in vivo diffusion tensor imaging assessment of male and female cocaine users (n = 75) and healthy controls (HC) (n = 58). Moreover, we performed an ex vivo large-scale proteomic analysis using liquid chromatography-tandem mass spectrometry in postmortem brains of patients with CUD (n = 8) and HC (n = 12). Compared with the HC, the CUD group showed significant reductions in global fractional anisotropy (FA) (p < 0.001), and an increase in global mean (MD) and radial diffusion (RD) (both p < 0.001). The results revealed that FA, RD, and MD alterations in the CUD group were widespread along the major WM tracts, after analysis using the tract-based special statistics approach. Global FA was negatively associated with years of CU (p = 0.0421) and female sex (p < 0.001), but not with years of alcohol or nicotine use. Concerning the fibers connecting the left to the right prefrontal cortex, Brodmann area 9 (BA9), the CUD group presented lower FA (p = 0.006) and higher RD (p < 0.001) values compared with the HC group. A negative association between the duration of CU in life and FA values in this tract was also observed (p = 0.019). Proteomics analyses in BA9 found 11 proteins differentially expressed between cocaine users and controls. Among these, were proteins related to myelination and neuroinflammation. In summary, we demonstrate convergent evidence from in vivo diffusion tensor imaging and ex vivo proteomics analysis of WM disruption in CUD.
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