Evidence map›Paper›PMID 33911067›Full record

ArticleCell death & disease2021

Tumor-derived exosomal circPSMA1 facilitates the tumorigenesis, metastasis, and migration in triple-negative breast cancer (TNBC) through miR-637/Akt1/β-catenin (cyclin D1) axis.

Su-Jin Yang, Dan-Dan Wang, Shan-Liang Zhong, Wen-Quan Chen, Feng-Liang Wang, Jian Zhang, Wen-Xiu Xu, Di Xu, Qian Zhang, Jian Li and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 2 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 145 citations in OpenAlex.

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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Su-Jin Yang *Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P.R. China.
Dan-Dan Wang *Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P.R. China.
Shan-Liang Zhong *The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210009, P.R. China.
Wen-Quan ChenDepartment of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P.R. China.
Feng-Liang WangDepartment of Obstetrics and Gynecology, Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, 210009, P.R. China.
Jian ZhangDepartment of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P.R. China.
Wen-Xiu XuDepartment of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P.R. China.
Di XuDepartment of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P.R. China.
Qian ZhangDepartment of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P.R. China.
Jian LiThe Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210009, P.R. China.
He-da ZhangDepartment of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P.R. China.
Jun-Chen HouDepartment of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P.R. China.
Ling MaoDepartment of Thyroid and Breast Surgery, the Affiliated Huai'an Hospital of Xuzhou Medical University, the Second People's Hospital of Huai'an, Huai'an, 223002, P.R. China.
Jin-Hai TangDepartment of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P.R. China. jhtang@njmu.edu.cn.
Jiangsu Province Hospital · CNNanjing Medical University · CNSecond People’s Hospital of Huai’an · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are increasingly gaining importance and attention due to their diverse potential functions and their value as diagnostic biomarkers (disease specific). This study aims to explore the novel mechanisms by which exosome-contained circRNAs promote tumor development and metastasis in TNBC. We identified increased circRNA circPSMA1 in TNBC cells, their exosomes, and serum exosomes samples from TNBC patients. The overexpression of circPSMA1 promoted TNBC cell proliferation, migration, and metastasis both in vitro and in vivo. Moreover, we investigated the tumor-infiltrating immune cells (TICs) or stromal components in immune microenvironment (IME), and identified the significant differences in the immune cells between TNBC and non-TNBC samples. Mechanistically, circPSMA1 acted as a "miRNAs sponge" to absorb miR-637; miR-637 inhibited TNBC cell migration and metastasis by directly targeted Akt1, which recognized as a key immune-related gene and affected downstream genes β-catenin and cyclin D1. Subsequent co-culture experiments also demonstrated that exosomes from TNBC carrying large amounts of circPSMA1 could transmit migration and proliferation capacity to recipient cells. Kaplan-Meier plots showed that high expression of Akt1 and low expression of mir-637 are highly correlated with poor prognosis in patients with lymph node metastasis of TNBC. Collectively, all these results reveal that circPSMA1 functions as a tumor promoter through the circPSMA1/miR-637/Akt1-β-catenin (cyclin D1) regulatory axis, which can facilitate the tumorigenesis, metastasis, and immunosuppression of TNBC. Our research proposes a fresh perspective on novel potential biomarkers and immune treatment strategies for TNBC.

Indexed as

beta CateninCarcinogenesisCell MovementCyclin D1ExosomesHumansMicroRNAsNeoplasm MetastasisProteasome Endopeptidase ComplexProto-Oncogene Proteins c-aktRNA, CircularTriple Negative Breast NeoplasmsTumor Microenvironmentbeta CateninCCND1 protein, humanCTNNB1 protein, humanCyclin D1MicroRNAsMIRN637 microRNA, humanProteasome Endopeptidase ComplexProto-Oncogene Proteins c-aktPSMA1 protein, humanRNA, Circular

Identifiers

PMID33911067
PMCPMC8080849
OpenAlexW3159854945

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.