Evidence map›Paper›PMID 33910997›Full record

ArticlemSphere2021

Vibrio cholerae Sialidase-Specific Immune Responses Are Associated with Protection against Cholera.

M Hasanul Kaisar, Mohammed Saruar Bhuiyan, Aklima Akter, Danial Saleem, Anita S Iyer, Pinki Dash, Al Hakim, Fahima Chowdhury, Ashraful Islam Khan, Stephen B Calderwood and 5 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Chimerolectins: Classification, structural architecture, and functional perspectives.Protein science : a publication of the Protein Society · 2025
    Review
  4. Frontiers in immunology · 2025
    Article
  5. Structural and enzymatic characterization of the sialidase SiaPG from Porphyromonas gingivalis.Acta crystallographica. Section F, Structural biology communications · 2023
    Article
  6. Article
  7. Frontiers in medicine · 2023
    Review
  8. Article
  9. A polyvalent multiepitope protein cross-protects againstProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Article
  11. Systemic, Mucosal, and Memory Immune Responses following Cholera.Tropical medicine and infectious disease · 2021
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

M Hasanul Kaisar *Infectious Diseases Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh.
Mohammed Saruar Bhuiyan *Infectious Diseases Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh.
Aklima AkterInfectious Diseases Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh.
Danial SaleemCollege of Physicians and Surgeons, Columbia University, New York, New York, USA.
Anita S IyerDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
Pinki DashInfectious Diseases Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh.
Al HakimInfectious Diseases Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh.
Fahima ChowdhuryInfectious Diseases Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh.
Ashraful Islam KhanInfectious Diseases Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh.
Stephen B CalderwoodDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jason B HarrisDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
Edward T RyanDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
Firdausi QadriInfectious Diseases Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh.
Richelle C Charles *Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-8881-1849
Taufiqur Rahman Bhuiyan *Infectious Diseases Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh taufiqur@icddrb.org.ORCID 0000-0003-3755-4763
International Centre for Diarrhoeal Disease Research · BDHarvard University · USColumbia University · US

Funding

Protecutive immunity to human cholera in BangladeshU01AI058935 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CALDERWOOD, STEPHEN B., RYAN, EDWARD T. · 2003 to 2014
$7.8M
Training program in vaccine development and public healthD43TW005572 · FIC · MASSACHUSETTS GENERAL HOSPITAL · PI QADRI, FIRDAUSI, RYAN, EDWARD T. · 2000 to 2025
$5.4M
O-Specific Polysaccharide Responses and CholeraR37AI106878 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Edward T. Ryan · 2020 to 2026
$5.1M
Antibody mediated protective immunity against choleraR01AI137164 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CHARLES, RICHELLE C, HARRIS, JASON B · 2018 to 2022
$3.9M
O-Specific Polysaccharide Responses and CholeraR01AI106878 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RYAN, EDWARD T. · 2014 to 2018
$3.7M
Mucosal associated invariant T (MAIT) cells in Vibrio cholerae infection and vaccinationR01AI130378 · NIAID · UNIVERSITY OF UTAH · PI LEUNG, DANIEL TED · 2017 to 2021
$1.8M
Humoral and adaptive immune responses study in Vibrio cholerae infectionK43TW010362 · FIC · INTERNATIONAL CTR/DIARRHOEAL DIS RES · PI BHUIYAN, MD TAUFIQUR RAHMAN · 2016 to 2020
$359k
Mucosal immune response to oral cholera vaccine Peru 15R03AI063079 · NIAID · INTERNATIONAL CTR/DIARRHOEAL DIS RES · PI QADRI, FIRDAUSI · 2005 to 2007
$158k
FIC NIH HHS D43 TW005572FIC NIH HHS K43 TW010362NIAID NIH HHS R01 AI106878NIAID NIH HHS R01 AI130378NIAID NIH HHS R01 AI137164NIAID NIH HHS R03 AI063079NIAID NIH HHS R37 AI106878NIAID NIH HHS U01 AI058935
6 · The paper itself

Abstract

Cholera remains a major public health problem in resource-limited countries. Vaccination is an important strategy to prevent cholera, but currently available vaccines provide only 3 to 5 years of protection. Understanding immune responses to cholera antigens in naturally infected individuals may elucidate which of these are key to longer-term protection seen following infection. We recently identified

Indexed as

Immunologic MemoryAdolescentAdultAge FactorsAntibodies, BacterialAntibody-Producing CellsB-LymphocytesChildChild, PreschoolCholeraFemaleHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MMaleAntibodies, BacterialImmunoglobulin AImmunoglobulin GImmunoglobulin MNeuraminidaseadultsantibodychildrencholerahumoralimmune responsememory B cellmucosalsialidaseVibrio cholerae

Identifiers

PMID33910997
PMCPMC8092141
OpenAlexW3159188896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.