Evidence map›Paper›PMID 33910896›Full record

ArticleScience advances2021

The hypothalamus predates the origin of vertebrates.

Laurence A Lemaire, Chen Cao, Peter H Yoon, Juanjuan Long, Michael Levine

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Deep homologies in chordate caudal central nervous systems.bioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. Cereblon influences the timing of muscle differentiation inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Laurence A LemaireLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0001-8439-8228
Chen CaoLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0003-0458-0834
Peter H YoonDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Juanjuan LongLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Michael LevineLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA. msl2@princeton.edu.ORCID 0000-0001-7629-0081
Princeton University · US

Funding

Developmental Patterning of the Anterior Neural Plate in a Simple ChordateR01NS076542 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LEVINE, MICHAEL STEVEN · 2012 to 2022
$3.4M
Decoding the dynamics and regulation of parental allelic expression at single-cell resolutionK99HD102584 · NICHD · PRINCETON UNIVERSITY · PI CAO, CHEN · 2021 to 2022
$231k
NICHD NIH HHS K99 HD102584NINDS NIH HHS R01 NS076542
6 · The paper itself

Abstract

The hypothalamus coordinates neuroendocrine functions in vertebrates. To explore its evolutionary origin, we describe integrated transcriptome/connectome brain maps for swimming tadpoles of

Identifiers

PMID33910896
PMCPMC8081355
OpenAlexW3157401921

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.