Evidence map›Paper›PMID 33910853›Full record

ArticleIn vivo (Athens, Greece)

Case Series of Pleomorphic Carcinoma of the Lung Treated With Immune Checkpoint Inhibitors.

Kana Hayashi, Kotaro Tokui, Minehiko Inomata, Kenji Azechi, Isami Mizushima, Naoki Takata, Chihiro Taka, Seisuke Okazawa, Kenta Kambara, Shingo Imanishi and 5 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Kana HayashiFirst Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Kotaro TokuiFirst Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Minehiko InomataFirst Department of Internal Medicine, Toyama University Hospital, Toyama, Japan; 9446-tym@umin.org.
Kenji AzechiFirst Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Isami MizushimaFirst Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Naoki TakataFirst Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Chihiro TakaFirst Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Seisuke OkazawaFirst Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Kenta KambaraFirst Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Shingo ImanishiFirst Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Toshiro MiwaFirst Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Ryuji HayashiDepartment of Medical Oncology, Toyama University Hospital, Toyama, Japan.
Shoko MatsuiFirst Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Satoshi NomuraRespiratory Medicine, Toyama City Hospital, Toyama, Japan.
Kazuyuki TobeFirst Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Toyama University Hospital · JPToyama City Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimWe report, herein, three cases of pleomorphic carcinoma of the lung treated with immune checkpoint inhibitors. Case 1: A 73-year-old man was diagnosed as having pleomorphic carcinoma of the lung and treated with pembrolizumab alone. However, he showed no response and died 4 months after the initiation of the treatment. Case 2: A 66-year-old man was diagnosed as having pleomorphic carcinoma of the lung. He was started on a combination regimen of pembrolizumab plus carboplatin plus nab-paclitaxel, and a remarkable response was observed. Case 3: A 49-year-old man was diagnosed as having pleomorphic carcinoma of the lung. He was started on pembrolizumab monotherapy as second-line treatment. Eleven months after the treatment initiation, computed tomography revealed the decrease of tumor diameter.

conclusionImmune checkpoint inhibitor therapy is expected to improve the prognosis of patients with pleomorphic carcinoma of the lung.

Indexed as

CarcinomaLung NeoplasmsAgedCarboplatinHumansImmune Checkpoint InhibitorsLungMaleMiddle AgedCarboplatinImmune Checkpoint InhibitorsImmune checkpoint inhibitorpembrolizumabpleomorphic carcinomasarcomatoid carcinoma

Identifiers

PMID33910853
PMCPMC8193335
OpenAlexW3159157507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.