Evidence map›Paper›PMID 33910638›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2021

Role of LncRNA score and PVT1 in primary hyperparathyroidism-- a preliminary study.

Dongxue Zhang, Bojun Wei, Long Li, Tao Jiang, Xiaoai Yao, Xin Liu, Yuyan Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dongxue ZhangDepartment of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, Beijing, 100038, China.
Bojun WeiDepartment of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Long LiDepartment of Pediatric Surgery, Capital Institute of Pediatrics, Beijing, 100020, China.
Tao JiangDepartment of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, Beijing, 100038, China. jiangtao6392@126.com.
Xiaoai YaoDepartment of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, Beijing, 100038, China.
Xin LiuDepartment of Medical Genetics and Developmental Biology, Capital Medical University, Beijing, 100069, China.
Yuyan SunDepartment of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, Beijing, 100038, China.
Capital Medical University · CNBeijing Shijitan Hospital · CNCapital Institute of Pediatrics · CN

Funding

Project of Science and Technology Research and Development of China Railway Corporation J2017Z602Project of Science and Technology Research and Development of China Railway Corporation J2017Z603Youth foundation of Beijing Shijitan Hospital 2018-q13
6 · The paper itself

Abstract

backgroundDysregulated lncRNA score and PVT1 expression may be involved in cancer. However, relationships of lncRNAs with hyperparathyroidism and parathyroid cancer (PC) diagnosis remain mysterious.

methodsUsing quantitative real-time polymerase chain reaction (RT-qPCR), expression profile of PVT1 was evaluated in 57 patients with primary hyperparathyroidism, including 11 with parathyroid cancer (PC) and 46 with parathyroid adenoma (PA).

resultsHigher levels of lncRNA score and PVT1 expression were associated with increased serum calcium level after water ingestion and PC risk (P < 0.05). Accordingly, lncRNA score and PVT1 expression were increased with varying degrees of hypercalcemia in PC. A higher level of lncRNA score (but not PVT1) was an independent risk factor of PC, with an AUC up to 0.872 (95% CI: 0.756-0.945, P < 0.001). Moreover, lncRNA score was more valuable (with AUC 0.974, sensitivity of 85.71% and specificity of 100%, respectively) than intact parathyroid hormone (iPTH) in predicting risk of PC among patients with hypercalcemia (especially based on greater AUC, P = 0.010).

conclusionIncreased lncRNA score is correlated with an elevated level of serum calcium, which may serve as a potential biomarker for PC diagnosis, especially with hypercalcemia.

Indexed as

Up-RegulationAdultAgedAged, 80 and overBiomarkersCalciumFemaleGene Expression RegulationHumansHyperparathyroidism, PrimaryMaleMiddle AgedReverse Transcriptase Polymerase Chain ReactionRNA, Long NoncodingSensitivity and SpecificityBiomarkersCalciumPVT1 long-non-coding RNA, humanRNA, Long NoncodingHypercalcemiaLncRNA scoreParathyroid cancerPVT1

Identifiers

PMID33910638
PMCPMC8082613
OpenAlexW3159771259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.