Evidence map›Paper›PMID 33910588›Full record

SynthesisJournal of translational medicine2021

Transplantation of mesenchymal stem cells for spinal cord injury: a systematic review and network meta-analysis.

Wei-Can Chen, Wei-Feng Liu, Yu-Yan Bai, Ying-Ying Zhou, Yan Zhang, Cong-Mei Wang, Shu Lin, He-Fan He

Open access · goldAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 9 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 9 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  17. Human dental pulp stem cells for spinal cord injury.Stem cell research & therapy · 2025
    Review
  18. Review
  19. Review
  20. Advance in pediatric spinal cord injury.Pediatric discovery · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Wei-Can ChenDepartment of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Wei-Feng LiuDepartment of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Yu-Yan BaiDepartment of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Ying-Ying ZhouDepartment of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Yan ZhangDepartment of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Cong-Mei WangDepartment of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Shu LinDepartment of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China. shulin1956@126.com.
He-Fan HeDepartment of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China. 15860905262@163.com.ORCID 0000-0003-0787-3173
Fujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) is a severe traumatic disease of the central nervous system, with a global prevalence of 236-4187 per million people. This meta-analysis aimed to evaluate the safety and efficacy of mesenchymal stem cells (MSCs) in treating patients with SCI as well as the optimal source and transplantation method of MSCs. PubMed, OVID, Cochrane, Web of Science, and China Biomedical Database were searched up until April 01, 2021. The study was conducted for five endpoints: American Spinal Injury Association (ASIA) motor and sensory score, ASIA grade improvement, Barthel Index (BI), and adverse reactions. Standard meta-analysis and network meta-analysis were performed using Stata 14.0. Eighteen studies with a total of 949 patients, were included in the meta-analysis. Standard meta-analysis showed that MSCs significantly improved ASIA motor score (P < 0.001), sensory score (P < 0.001), ASIA grade (P < 0.001), and BI (P < 0.001) compared to rehabilitation. In addition, in the network meta-analysis, autologous MSCs significantly improved the ASIA motor [MD = 8.01, 95% CI (4.27, 11.76)], sensory score [MD = 17.98, 95% CI (10.04, 25.91)], and BI [MD = 7.69, 95% CI (2.10, 13.29)] compared to rehabilitation. Similarly, compared to rehabilitation, intrathecal injection (IT) of MSCs significantly improved the ASIA motor [MD = 7.97, 95% CI (4.40, 11.53)] and sensory score [MD = 19.60, 95% CI (9.74, 29.46)]. Compared to rehabilitation, however, only the IL of MSCs was associated with more adverse reactions [OR = 17.82, 95% CI (2.48, 128.22)]. According to the results of SUCRA, both autologous MSCs and IT transplantation approaches most improved the neurological function in SCI patients. Cell transplantation using MSCs is effective in patients with SCI and IT of autologous MSCs may be more beneficial.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationSpinal Cord InjuriesChinaHumansSpinal Cord

Identifiers

PMID33910588
PMCPMC8082850
OpenAlexW3157429356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.