ArticleCephalalgia : an international journal of headache2021
Photophobia and allodynia in persistent post-traumatic headache are associated with higher disease burden.
Article in Cephalalgia : an international journal of headache, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Neuropsychological influences on visual photosensitivity and its treatment in traumatic brain injury.BMJ open ophthalmology · 2026Article
- Light Filtering Lenses and Visual Photosensitivity in Individuals With Traumatic Brain Injury.Investigative ophthalmology & visual science · 2026Article
- Symptoms of allodynia and pain thresholds amongst those with acute post-traumatic headache attributed to mild traumatic brain injury: a prospective, longitudinal study.The journal of headache and pain · 2025Article
- Association Between Interictal Sensory Hypersensitivities and Vestibular Symptoms in Migraine: A Cross-Sectional Study.Brain and behavior · 2025Article
- Symptoms of Allodynia and Pain Thresholds Amongst Those with Acute Post-Traumatic Headache Attributed to Mild Traumatic Brain Injury: A Prospective, Longitudinal Study.Research square · 2025Article
- Pretreatment with an anti-CGRP monoclonal antibody attenuates mild TBI-induced tactile hypersensitivity in mice.The journal of headache and pain · 2025Article
- Conservative Management of Acute Sports-Related Concussions: A Narrative Review.Healthcare (Basel, Switzerland) · 2024Review
- Sensory hypersensitivities are associated with post-traumatic headache-related disability.Headache · 2023Article
- Validation of the Utah Photophobia Symptom Impact Scale (version 2) as a headache-specific photophobia assessment tool.Headache · 2023Article
- Review
- Photosensitivity Is Associated with Chronic Pain following Traumatic Brain Injury.Journal of neurotrauma · 2022Article
- The value of brain MRI functional connectivity data in a machine learning classifier for distinguishing migraine from persistent post-traumatic headache.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Mild traumatic brain injury affects the features of migraine.The journal of headache and pain · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo assess photophobia and allodynia in subjects with post-traumatic headache and examine how these sensory hypersensitivities associate with clinical measures of disease burden.
backgroundPost-traumatic headache is the most frequent and disabling long-term consequence of mild traumatic brain injury. There is evidence of sensory dysfunction in acute post-traumatic headache, and it is known from other headache conditions that sensory amplifications correlate with more severe disease. However, systematic studies in post-traumatic headache are surprisingly scarce.
methodsWe tested light and tactile sensitivity, along with measures of disease burden, in 30 persistent post-traumatic headache subjects and 35 controls.
resultsIn all, 79% of post-traumatic headache subjects exhibited sensory hypersensitivity based on psychophysical assessment. Of those exhibiting hypersensitivity, 54% exhibited both light and tactile sensitivity. Finally, sensory thresholds were correlated across modalities, as well as with headache attack frequency.
conclusionsIn this study, post-traumatic headache subjects with both light and tactile sensitivity had significantly higher headache frequencies and lower sensitivity thresholds to both modalities, compared to those with single or no sensory hypersensitivity. This pattern suggests that hypersensitivity across multiple modalities may be functionally synergistic, reflect a higher disease burden, and may serve as candidate markers of disease.
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