Evidence map›Paper›PMID 33910053›Full record

ArticleAmerican journal of ophthalmology2021

Rates of Retinal Nerve Fiber Layer Thinning in Distinct Glaucomatous Optic Disc Phenotypes in Early Glaucoma.

Ryan Caezar C David, Sasan Moghimi, Eren Ekici, Jiun L Do, Huiyuan Hou, James A Proudfoot, Alireza Kamalipour, Takashi Nishida, Christopher A Girkin, Jeffrey M Liebmann and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ryan Caezar C DavidFrom the Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California (R.C.C.D., S.M., E.E., J.L.D., H.H., J.A.P., A.K., T.N., R.N.W.), San Diego, La Jolla, California.
Sasan MoghimiFrom the Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California (R.C.C.D., S.M., E.E., J.L.D., H.H., J.A.P., A.K., T.N., R.N.W.), San Diego, La Jolla, California.
Eren EkiciFrom the Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California (R.C.C.D., S.M., E.E., J.L.D., H.H., J.A.P., A.K., T.N., R.N.W.), San Diego, La Jolla, California.
Jiun L DoFrom the Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California (R.C.C.D., S.M., E.E., J.L.D., H.H., J.A.P., A.K., T.N., R.N.W.), San Diego, La Jolla, California.
Huiyuan HouFrom the Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California (R.C.C.D., S.M., E.E., J.L.D., H.H., J.A.P., A.K., T.N., R.N.W.), San Diego, La Jolla, California.
James A ProudfootFrom the Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California (R.C.C.D., S.M., E.E., J.L.D., H.H., J.A.P., A.K., T.N., R.N.W.), San Diego, La Jolla, California.
Alireza KamalipourFrom the Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California (R.C.C.D., S.M., E.E., J.L.D., H.H., J.A.P., A.K., T.N., R.N.W.), San Diego, La Jolla, California.
Takashi NishidaFrom the Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California (R.C.C.D., S.M., E.E., J.L.D., H.H., J.A.P., A.K., T.N., R.N.W.), San Diego, La Jolla, California.
Christopher A GirkinDepartment of Ophthalmology and Visual Science, Callahan Eye Hospital, University of Alabama-Birmingham (C.A.G.), Alabama and.
Jeffrey M LiebmannBernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center (J.M.L.), New York, New York, USA.
Robert N WeinrebFrom the Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California (R.C.C.D., S.M., E.E., J.L.D., H.H., J.A.P., A.K., T.N., R.N.W.), San Diego, La Jolla, California. Electronic address: rweinreb@health.ucsd.edu.
University of California San Diego · USColumbia University Irving Medical Center · USUniversity of Alabama at Birmingham Hospital · US

Funding

Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Derek Stuart Welsbie · 2012 to 2026
$10.3M
Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography AngiographyR01EY029058 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEINREB, ROBERT N · 2018 to 2024
$4.2M
African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progressionR01EY026574 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAZIO, MASSIMO ANTONIO, GIRKIN, CHRISTOPHER ANTHONY · 2017 to 2020
$2.6M
OCULAR HYPERTENSION TREATMENT STUDY (OHTS)U10EY010427 · NEI · NEW YORK MEDICAL COLLEGE · PI LIEBMANN, JEFFREY M · 1994 to 2008
$1.2M
Development of Optic Nerve Relays to Restore Retinofugal ConnectionsK08EY033032 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DO, JIUN LAP · 2021 to 2023
$736k
NEI NIH HHS K08 EY033032NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY026574NEI NIH HHS R01 EY029058NEI NIH HHS U10 EY010427
6 · The paper itself

Abstract

purposeTo compare spectral-domain optical coherence tomography (SDOCT) measured circumpapillary retinal nerve fiber layer (cpRNFL) among 4 glaucomatous optic disc phenotypes in early glaucoma.

designClinical cohort study

methodsIn this study, 218 early glaucoma eyes that had at least 3 years of follow-up and a minimum of 4 SDOCT scans were recruited. The optic discs were classified into 4 types based on appearance: 76 generalized cup enlargement (GE), 53 focal ischemic (FI), 22 myopic glaucomatous (MY), and 67 senile sclerotic (SS). A linear mixed effects model was used to compare the rates of global and regional cpRNFL thinning among optic disc phenotypes.

resultsAfter adjusting for confounders, the SS group (mean [95% CI]: -1.01 [-1.30, -0.73] µm/y) had the fastest mean rate of global cpRNFL thinning followed by FI (-0.77 [-0.97, -0.57] µm/y), MY (0.59 [-0.81, -0.36] µm/y), and GE (-0.58 [-0.75, -0.40] µm/y) at P < .001. The inferior temporal sector had the fastest rate of cpRNFL thinning among the regional measurements except for the MY group (-0.68 [-1.10, -0.26] µm/y, P = .002). In the multivariable analysis, GE (P = .002) and MY (P = .010) phenotypes were associated with significantly slower global rates of cpRNFL thinning compared with the SS phenotype.

conclusionsRates of cpRNFL thinning were different among the 4 glaucomatous optic disc phenotypes. Those patients with early glaucoma with SS phenotype have the fastest cpRNFL thinning. These patients may benefit from more frequent monitoring and the need to advance therapy if cpRNFL thinning is detected.

Indexed as

GlaucomaGlaucoma, Open-AngleOptic DiskHumansIntraocular PressureNerve FibersPhenotypeTomography, Optical CoherenceVisual Fields

Identifiers

PMID33910053
PMCPMC9467437
OpenAlexW3157465708

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.