Evidence map›Paper›PMID 33909977›Full record

ArticleJournal of the American Chemical Society2021

Origin and Control of Chemoselectivity in Cytochrome

Marc Garcia-Borràs, S B Jennifer Kan, Russell D Lewis, Allison Tang, Gonzalo Jimenez-Osés, Frances H Arnold, K N Houk

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Article
  3. A Divergent CytochromebioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Expanding beyond the capability of nature.Nature chemical biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. How to Stabilize Carbenes in Enzyme Active Sites without Metal Ions.Journal of the American Chemical Society · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Marc Garcia-BorràsDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.ORCID 0000-0001-9458-1114
S B Jennifer KanDivision of Chemistry and Chemical Engineering 210-41, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States.ORCID 0000-0001-6371-8042
Russell D LewisDivision of Biology and Bioengineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States.ORCID 0000-0002-5776-7347
Allison TangDivision of Chemistry and Chemical Engineering 210-41, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States.
Gonzalo Jimenez-OsésCIC bioGUNE, Bizkaia Technology Park, Building 800, 48170 Derio, Spain.ORCID 0000-0003-0105-4337
Frances H ArnoldDivision of Biology and Bioengineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States.ORCID 0000-0002-4027-364X
K N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.ORCID 0000-0002-8387-5261
California Institute of Technology · USUniversity of California, Los Angeles · USCIC bioGUNE · ES

Funding

PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRYT32GM007616 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 1985 to 2019
$22.9M
Steroselectivity of Synthetically Valuable Enzyme CatalystsR01GM124480 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOUK, KENDALL N · 2018 to 2021
$1.1M
NIGMS NIH HHS R01 GM124480NIGMS NIH HHS T32 GM007616
6 · The paper itself

Abstract

A cytochrome

Indexed as

BiocatalysisCytochromes cHydrogenMethaneMolecular StructureNitrogenSiliconcarbeneCytochromes cHydrogenMethaneNitrogenSilicon

Identifiers

PMID33909977
PMCPMC9292473
OpenAlexW3158747957

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.