Evidence map›Paper›PMID 33909885›Full record

ArticleRheumatology (Oxford, England)2022

Identifying parameters associated with delayed diagnosis in axial spondyloarthritis: data from the European map of axial spondyloarthritis.

Marco Garrido-Cumbrera, Victoria Navarro-Compán, Christine Bundy, Raj Mahapatra, Souzi Makri, José Correa-Fernández, Laura Christen, Carlos Jesús Delgado-Domínguez, Denis Poddubnyy, EMAS Working Group

Open access · hybridAbstract read
In one paragraph

Article in Rheumatology (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Marco Garrido-CumbreraHealth & Territory Research (HTR), Universidad de Sevilla, Seville, Spain.ORCID 0000-0001-9727-1189
Victoria Navarro-CompánUniversity Hospital La Paz, IdiPAZ, Madrid, Spain.ORCID 0000-0002-4527-852X
Christine BundySchool of Healthcare Sciences, Cardiff University, Cardiff, United Kingdom.
Raj MahapatraAxial Spondyloarthritis International Federation (ASIF), London, UK.
Souzi MakriCyprus League Against Rheumatism, Nicosia, Cyprus.
José Correa-FernándezHealth & Territory Research (HTR), Universidad de Sevilla, Seville, Spain.
Laura ChristenNovartis Pharma AG, Basel, Switzerland.
Carlos Jesús Delgado-DomínguezHealth & Territory Research (HTR), Universidad de Sevilla, Seville, Spain.
Denis PoddubnyyCharité-Universitätsmedizin Berlin.ORCID 0000-0002-4537-6015
EMAS Working Group
Multiple Sclerosis International Federation · GBUniversidad de Sevilla · ESCardiff University · GBGerman Rheumatism Research Centre · DENovartis (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify the parameters associated with self-reported diagnostic delay (DD) in axial spondyloarthritis (axSpA) patients across Europe.

methodsData from 2652 patients from 13 countries who participated in the European Map of Axial Spondyloarthritis (EMAS) were collected through an online survey (2017-2018). DD was calculated as the difference between age at diagnosis and age at symptom onset reported by participants. Associations between DD and sociodemographic characteristics, as well as disease-related factors were explored through univariable and multivariable linear regression analysis.

resultsAverage DD was 7.4  (8.4) years with a variation between countries. The variables associated with longer DD in the final multivariable regression model were: younger age at symptom onset (b = -0.26; 95% CI: -0.28, -0.23), female gender (b = 1.34; 95% CI: 0.73, 1.96) and higher number of health-care professionals (HCPs) seen before diagnosis (b = 1.19; 95% CI: 0.95, 1.43). There was a significant interaction between the female gender and the number of HCPs seen before diagnosis. A substantial variation of the DD across European countries was observed.

conclusionIn this sample of axSpA patients, average DD was greater than 7 years. Younger age at symptom onset, female gender, higher number of HCPs seen before diagnosis, and being diagnosed by rheumatologist were the parameters associated with a longer DD in axSpA. These findings indicate a need for continuing efforts dedicated to recognition of patients with a high probability of axSpA on the level of non-rheumatology specialists and facilitating referral to a rheumatologist for timely diagnosis.

Indexed as

AdultAge of OnsetAxial SpondyloarthritisCross-Sectional StudiesDelayed DiagnosisEuropeFemaleHumansMaleRisk FactorsSex FactorsSurveys and QuestionnairesTime Factorsaxial spondyloarthritisdiagnostic delayEuropepatient journeypatient-reported outcomes

Identifiers

PMID33909885
PMCPMC8824419
OpenAlexW3157780157

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.