Evidence map›Paper›PMID 33909821›Full record

ArticleActa cirurgica brasileira2021

Effects of dietary creatine supplementation on kidney and striated skeletal muscles of rats submitted to ischemia and reperfusion of hind limbs.

Antonio Augusto Moreira Neto, Acácio Francisco Neto, Fernanda Macedo Dos Reis Moreira, Lawani Rigopoulos, Douglas Tsunemi, Marco Antônio Soufen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Antonio Augusto Moreira NetoPhD, Assistant Professor. Universidade de Mogi das Cruzes - College of Medicine - Department of Vascular Surgery - Mogi das Cruzes (SP), Brazil.ORCID http://orcid.org/0000-0002-2283-9873
Acácio Francisco NetoPhD, Assistant Professor. Universidade de Mogi das Cruzes - College of Medicine - Department of Vascular Surgery - Mogi das Cruzes (SP), Brazil.ORCID http://orcid.org/0000-0002-0676-6790
Fernanda Macedo Dos Reis MoreiraGraduate student. Universidade de Mogi das Cruzes - College of Nutrition - Department of Vascular Surgery - Mogi das Cruzes (SP), Brazil.ORCID http://orcid.org/0000-0002-5935-2583
Lawani RigopoulosGraduate student. Universidade de Mogi das Cruzes - College of Medicine - Department of Vascular Surgery - Mogi das Cruzes (SP), Brazil.ORCID http://orcid.org/0000-0002-2642-3074
Douglas TsunemiGraduate student. Universidade de Mogi das Cruzes - Department of Vascular Surgery - Mogi das Cruzes (SP), Brazil.ORCID http://orcid.org/0000-0001-7615-8419
Marco Antônio SoufenPhD, Assistant Professor. Universidade de Mogi das Cruzes - College of Medicine - Department of Pathology - Mogi das Cruzes (SP), Brazil.ORCID http://orcid.org/0000-0002-1663-0379
Universidade de Mogi das Cruzes · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effect of creatine supplementation in the diet of rats subjected to ischemia and reperfusion of hind limbs.

methodsEighteen male Wistar rats were randomized to receive dietary creatine supplementation (G1) or no supplementation (G2), before being subjected to 4 h of ischemia followed by 4 h of reperfusion. In addition, 10 rats (G3) underwent the same surgical procedure, without ischemia, but with supplementation. After reperfusion, kidney and musculature were evaluated for histological damage and serum levels of alanine aminotransferase, urea and creatinine were obtained.

resultsThe urea dosage showed significant differences between the groups (averages G1 = 155.1; G2 = 211.27; G3 = 160.42). Histological analysis found significant differences between G1 and G2 (but not between G1 and G3) in renal myoglobin cylinders and vacuolar degeneration variables and in hypereosinophilia and karyopyknosis variables in muscle fibers. There were no significant differences in the other variables studied.

conclusionsCreatine supplementation was related to fewer histological lesions, as well as lower levels of plasma urea, which may suggest a protective effect against lesions caused by ischemia and reperfusion of posterior paws muscles in Wistar rats.

Indexed as

CreatineReperfusion InjuryAnimalsDietDietary SupplementsIschemiaKidneyMaleMuscle, SkeletalRatsRats, WistarReperfusionCreatine

Identifiers

PMID33909821
PMCPMC8128404
OpenAlexW3152572719

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.