ArticleArquivos brasileiros de cardiologia2021
Mortal Interaction Between Hemophagocytic Syndrome and Newly Developed Heart Failure.
Article in Arquivos brasileiros de cardiologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Multicenter machine learning prediction of postoperative heart failure in elderly patients highlighting inflammatory markers, metabolic comorbidities, and perioperative tachycardia.Frontiers in medicine · 2026Article
- Hemodynamic homeostasis disequilibrium in critical illness.Frontiers in physiology · 2025Review
- Classification and Regression Tree Analysis in Adult Hemophagocytic Syndrome: Identifying Acute Heart Failure Predictors in ICU Patients.Journal of inflammation research · 2024Article
- Prognostic Efficacy of Complete Blood Count Indices for Assessing the Presence and the Progression of Myxomatous Mitral Valve Disease in Dogs.Animals : an open access journal from MDPI · 2023Article
- Short Editorial Neutrophil-To-Lymphocyte Ratio and Abdominal Aortic Atherosclerosis Among Asymptomatic Individuals.Arquivos brasileiros de cardiologia · 2022Article
- Analysis of Prognostic Risk Factors and Establishment of Prognostic Scoring System for Secondary Adult Hemophagocytic Syndrome.Current oncology (Toronto, Ont.) · 2022Article
- Hyperinflammatory Syndrome as a Cardiac Injury Mechanism.Arquivos brasileiros de cardiologia · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHemophagocytic syndrome (HPS) ia s devastating hyperinflammatory syndrome. Heart failure (HF) with preserved ejection fraction (HFpEF) status is closely correlated with increased inflammation, both systemic and intramyocardial.
objectivesThis study sought to determine mortality predictors and reliable follow-up parameters in HPS that developed HFpEF during the clinical course.
methodThirty-nine patients, diagnosed as HPS, according to HLH 2004 diagnostic criteria, with an HScore of ≥169 and proven bone marrow aspiration or biopsy, were recruited retrospectively. Both traditional, serum C-reactive protein, albumin and ferritin levels with lymphocyte, and platelet counts, as well as non-traditional risk factors, neutrophil-to-lymphocyte count (NLR), monocyte-to-lymphocyte count (MLR), mean platelet volume (MPV), and N-Terminal pro-brain natriuretic peptide (NTproBNP), were investigated retrospectively. The relationship between time-changed laboratory values both among themselves and with mortality. The overall significance level was set at 5%.
resultsThis study showed that temporal change of cardiothoracic ratio (CTR), serum NTproBNP, ferritin, CRP, and albumin levels were detected as mortality predictors (p<0.05, for all) in the univariate analysis. Lymphocyte and platelet counts with NLR and MPV values were also significant (p<0.05). The relationship between NT-proBNP and increased systemic inflammatory markers proved to be significant. In addition to traditional risk factors, serum ferritin levels, NLR, MLR, and MPV levels also proved to be significantly correlated with each other.
conclusionAccompanied by reliable follow-up parameters, rapid diagnosis and aggressive anti-inflammatory treatment with tight volume control can be life-saving in HPS patients who suffer from HFpEF. Close monitoring of inflammation may predict the outcome of patients suffering from HFpEF.
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