Evidence map›Paper›PMID 33909662›Full record

Trial reportPloS one2021

Effect of focused ultrasound cavitation augmented with aerobic exercise on abdominal and intrahepatic fat in patients with non-alcoholic fatty liver disease: A randomized controlled trial.

Mona Mohamed Taha, Yasser M Aneis, Heba Mohamed Mohamady, Alrasheedy S A, Shereen Hamed Elsayed

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04161703 (Effect of Focused Ultrasound on Abdominal and Intrahepatic Fat in Patients With Non-alcoholic Fatty Liver Disease), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04161703 nacompletednot on this map

Effect of Focused Ultrasound on Abdominal and Intrahepatic Fat in Patients With Non-alcoholic Fatty Liver Disease

TypeinterventionalSponsorCairo UniversityRan2019 to 2020Enrolled50ConditionsFatty LiverArmsfocused ultrasound, diet and exercise, diet and exercise
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Investigating the Metabolic Effects of Ultrasound-Induced Lipolysis.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Mona Mohamed TahaDepartment of Rehabilitation, College Of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia.ORCID 0000-0001-9080-5061
Yasser M AneisDepartment of Basic Science, Faculty of Physical Therapy, Cairo University, Giza, Egypt.ORCID 0000-0001-6779-5985
Heba Mohamed MohamadyDepartment of Surgery, Faculty of Physical Therapy, Cairo University, Giza, Egypt.
Alrasheedy S ADepartment of Internal Medicine, EL Sahel Teaching Hospital, Giza, Egypt.
Shereen Hamed ElsayedDepartment of Rehabilitation, College Of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia.
Cairo University · EGPrincess Nourah bint Abdulrahman University · SAShebin Teaching Hospital · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe study aimed to examine the effect of focused ultrasound cavitation augmented with aerobic exercise on localized abdominal and intrahepatic fat in fatty liver patients.

methods34 fatty liver patients aged 30-45 with a body mass index (BMI) of 30-40 kg/m2 were randomly assigned into two equally numbered groups. Group A received focused ultrasound cavitation and moderate aerobic exercise for three months, while Group B (control group) received moderate aerobic exercise only. Abdominal subcutaneous fat volume, visceral fat volume, liver-to-spleen ratio (L/S ratio), body weight, BMI, and waist circumference were measured both before and after the study period.

resultsBoth groups showed significant improvements in subcutaneous fat volume, visceral fat volume, body weight, BMI, and waist circumference relative to baseline where (P < 0.001), with a higher percentage in group A. L/S ratio only showed a significant improvement in group A. Between-group differences were noteworthy regarding L/S ratio and waist circumference where (P < 0.0001).

conclusionWhile substantial risky measures in non-alcoholic fatty liver disease have been modified by aerobic exercise, its combination with focused ultrasound cavitation causes more notable effects on the reduction of abdominal and intrahepatic fat, making it a superior option.

trial registrationClinicalTrials.gov: NCT04161703.

Indexed as

Abdominal FatAdipose TissueAdultBody Mass IndexExerciseFemaleHumansLipectomyLiverMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseSpleenTomography, X-Ray ComputedUltrasonic TherapyUltrasonic Waves

Identifiers

PMID33909662
PMCPMC8081198
OpenAlexW3157725231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.