ArticlePloS one2021
Association of adverse prenatal exposure burden with child psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The effects of prenatal psychosocial work stress on adverse pregnancy outcomes: A comprehensive systematic review and meta-analysis.Scandinavian journal of work, environment & health · 2025Pooled it
- Ancestral, Pregnancy, and Negative Early-Life Risks Shape Children's Brain (Dis)similarity to Schizophrenia.Biological psychiatry · 2023Pooled it
- Parental drug use disorders and youth psychopathology: Meta-analytic review.Drug and alcohol dependence · 2023Pooled it
- Linking maternal childhood maltreatment to health-related and psychosocial risk factors during pregnancy: intergenerational implications for early child development.European journal of psychotraumatology · 2026Article
- Associations Between Teenage Motherhood, Perinatal Cortical Maturation, and Risk of Psychopathology in Children: The Mediating Role of Pregnancy Complications.Biological psychiatry global open science · 2026Article
- Prenatal and early-life determinants of neurodevelopment: A decade of discoveries and new directions in ABCD.Developmental cognitive neuroscience · 2026Review
- Neurodevelopmental outcomes following prenatal cannabinoid exposure: a systematic review.European child & adolescent psychiatry · 2026Review
- Before Birth, Beyond Childhood: Understanding the Influence of Prenatal Substance Exposure on Psychiatric Diagnoses.medRxiv : the preprint server for health sciences · 2026Article
- What we have learned about adolescent mental health and where we are going after a decade with the Adolescent Brain Cognitive Development Study.Developmental cognitive neuroscience · 2026Review
- Prenatal Adversities and Risk of Persistent Youth Psychopathology and Altered Cortical Thinning.JAMA psychiatry · 2026Article
- Developmental Trajectories of Positive Expectancies of Cannabis Use Effects Among Early Adolescents: Longitudinal Observational Study Using Latent Class Growth Analysis.JMIR public health and surveillance · 2026Observational
- Considerations When Accounting for Race and Ethnicity in Studies of Poverty and Neurodevelopment.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Predicting 5-year-olds mental health at birth: development and internal validation of a multivariable model using the prospective ELFE birth cohort.European child & adolescent psychiatry · 2025Article
- Perinatal insult dimensions and developmental trajectories of psychotic-like experiences.Schizophrenia (Heidelberg, Germany) · 2025Article
- Association of Adverse Prenatal Exposure Burden with Persistent Psychopathology and Accelerated Cortical Thinning in Youth.medRxiv : the preprint server for health sciences · 2025Article
- Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children.Biological psychiatry global open science · 2025Article
- Sibling Control Analysis of Perinatal Health and Family Environment Factors Related to Childhood ADHD Symptoms.medRxiv : the preprint server for health sciences · 2025Article
- Prenatal Tobacco and Alcohol Exposure and Cortical Change Among Youths.JAMA network open · 2025Article
- Dimensions of perinatal and childhood adversities both merge and remain distinct.Child abuse & neglect · 2025Article
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveNumerous adverse prenatal exposures have been individually associated with risk for psychiatric illness in the offspring. However, such exposures frequently co-occur, raising questions about their cumulative impact. We evaluated effects of cumulative adverse prenatal exposure burden on psychopathology risk in school-aged children.
methodsUsing baseline surveys from the U.S.-based Adolescent Brain and Cognitive Development (ABCD) Study (7,898 non-adopted, unrelated children from 21 sites, age 9-10, and their primary caregivers), we examined 8 retrospectively-reported adverse prenatal exposures in relation to caregiver-reported total and subscale Child Behavior Checklist (CBCL) scores. We also assessed cumulative effects of these factors on CBCL total as a continuous measure, as well as on odds of clinically significant psychopathology (CBCL total ≥60), in both the initial set and a separate ABCD sample comprising an additional 696 sibling pairs. Analyses were conducted before and after adjustment for 14 demographic and environmental covariates.
resultsIn minimally and fully adjusted models, 6 exposures (unplanned pregnancy; maternal alcohol, marijuana, and tobacco use early in pregnancy; pregnancy complications; and birth complications) independently associated with significant but small increases in CBCL total score. Among these 6, none increased the odds of crossing the threshold for clinically significant symptoms by itself. However, odds of exceeding this threshold became significant with 2 exposures (OR = 1.86, 95% CI 1.47-2.36), and increased linearly with each level of exposure (OR = 1.39, 95% CI 1.31-1.47), up to 3.53-fold for ≥4 exposures versus none. Similar effects were observed in confirmatory analysis among siblings. Within sibling pairs, greater discordance for exposure load associated with greater CBCL total differences, suggesting that results were not confounded by unmeasured family-level effects.
conclusionChildren exposed to multiple common, adverse prenatal events showed dose-dependent increases in broad, clinically significant psychopathology at age 9-10. Fully prospective studies are needed to confirm and elaborate upon this pattern.
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