SynthesisPLoS neglected tropical diseases2021
Serology for the diagnosis of human hepatic cystic echinococcosis and its relation with cyst staging: A systematic review of the literature with meta-analysis.
Synthesis in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Foodborne and neglected parasitic zoonoses in Ethiopian red meat animals: insights from a systematic review and meta-analysis.Frontiers in veterinary science · 2025Pooled it
- Treatment of uncomplicated hepatic cystic echinococcosis (hydatid disease).The Cochrane database of systematic reviews · 2024Pooled it
- Cardiac cystic echinococcosis-A systematic review and analysis of the literature.PLoS neglected tropical diseases · 2024Pooled it
- From conventional to next-generation diagnostics in cystic echinococcosis: integrating serology, ultrasonography, and molecular tools: a review.Abdominal radiology (New York) · 2026Review
- Recent advances in clinical and laboratory diagnosis of hydatid cyst: from imaging to recombinant and nanobiosensor-based approaches.Infection · 2026Review
- Ultrasound-Based Staging and Its Impact on Clinical Management of Hepatic Hydatid Cysts in an Endemic Setting: A Cross-Sectional Study in Eastern Afghanistan.Tropical medicine and infectious disease · 2026Article
- High efficacy of an in-house antigen B ELISA for diagnosing human cystic echinococcosis compared with a commercial kit and a cell-free DNA assay.Scientific reports · 2026Article
- Congenital non-parasitic hepatic cyst complicated by hepatoduodenal fistula: a rare case report.International journal of surgery case reports · 2026Article
- Intramuscular Hydatid Cyst Involving the Hamstring Muscles: A Rare Localization.Journal of clinical practice and research · 2026Article
- Cystic echinococcosis in Austria 2009-2024: national surveillance and two rare cases of musculoskeletal manifestations including clinical management strategies.BMC musculoskeletal disorders · 2026Article
- Diagnostic Pathways and Genotyping of Cases ofPathogens (Basel, Switzerland) · 2026Article
- A cyst in every corner: multiorgan hydatid disease affecting hepatic, pancreatic, splenic, pelvic, and pulmonary sites.International journal of surgery case reports · 2026Article
- Abdominopelvic hydatid disease during pregnancy: a systematic review of the literature.Frontiers in global women's health · 2026Review
- Recent advances in the detection and treatment of hydatid cysts by nanomaterial-based carriers.Iranian journal of basic medical sciences · 2026Review
- Clinical profile, imaging characteristics, and operative outcomes of pediatric cystic echinococcosis in Northern Jordan: a single-center retrospective study.Frontiers in surgery · 2026Article
- Imaging comparisons of cystic echinococcosis in HIV-positive and HIV-negative patients.SA journal of radiology · 2026Article
- Ultrasound-based population survey for abdominal cystic echinococcosis in Albania: Results from the NDTND project.PLoS neglected tropical diseases · 2025Article
- First In Silico Study of TwoInternational journal of molecular sciences · 2025Article
- Design and evaluation of a novel direct hemagglutination test based on a recombinant protein for diagnosis of cystic echinococcosis.Parasites & vectors · 2025Article
- Cardiopulmonary Echinococcus Infection.The American journal of tropical medicine and hygiene · 2025Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnosis of cystic echinococcosis (CE) is primarily based on imaging, while serology should be applied when imaging is inconclusive. CE cyst stage has been reported among the most important factors influencing the outcome of serodiagnosis. We performed a systematic review and meta-analysis of the relation between cyst stage of hepatic CE and diagnostic sensitivity of serological tests, to evaluate whether their relation is a consistent finding and provide guidance for the interpretation of results of serological tests. METHODOLOGY/PRINCIPAL
findingsMEDLINE, EMBASE, CENTRAL, and Lilacs databases were searched on December 1st 2019. Original studies published after 2003 (year of publication of the CE cyst classification), reporting sensitivity of serological tests applied to the diagnosis of human hepatic CE, as diagnosed and staged by imaging, were included. The quality of studies was assessed using the Newcastle-Ottawa Scale. Data from 14 studies were included in the meta-analysis. Summary estimates of sensitivities and 95% confidence intervals were obtained using random effects meta-analysis. Overall, test sensitivity was highest in the presence of CE2 and CE3 (CE3a and/or CE3b), and lowest in the presence of CE5 and CE4 cysts. ELISA, ICT and WB showed the highest sensitivities, while IHA performed worst. CONCLUSIONS/SIGNIFICANCE: The results of our study confirm the presence of a clear and consistent relation between cyst stage and serological tests results. Limitations of evidence included the heterogeneity of the antigenic preparations used, which prevented to determine whether the relation between cyst stage and sensitivity was influenced by the type of antigenic preparation, the paucity of studies testing the same panel of sera with different assays, and the lack of studies assessing the performance of the same assay in both field and hospital-based settings. Our results indicate the absolute need to consider cyst staging when evaluating serological results of patients with hepatic CE.
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