Evidence map›Paper›PMID 33909280›Full record

ArticleAging clinical and experimental research2021

Dietary calcium intake in a cohort of individuals evaluated for low bone mineral density: a multicenter Italian study.

Elisa Cairoli, Carmen Aresta, Luca Giovanelli, Cristina Eller-Vainicher, Silvia Migliaccio, Sandro Giannini, Andrea Giusti, Claudio Marcocci, Stefano Gonnelli, Gian Carlo Isaia and 4 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  9. Comment on: Abdalbary et al. Impact of urinary calcium excretion on kidney, bone, and cardiovascular systems in patients with bone biopsy proven osteoporosis: a longitudinal long-term follow-up study. Osteoporos Int. 2023 Apr;34(4):763-774.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 2 countries.

Elisa CairoliUnit for Bone Metabolism Disease and Diabetes and Lab of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Via Magnasco 2, 20149, Milan, Italy.
Carmen ArestaUnit for Bone Metabolism Disease and Diabetes and Lab of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Via Magnasco 2, 20149, Milan, Italy.
Luca GiovanelliUnit for Bone Metabolism Disease and Diabetes and Lab of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Via Magnasco 2, 20149, Milan, Italy.
Cristina Eller-VainicherUnit of Endocrinology, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Silvia MigliaccioDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
Sandro GianniniDepartment of Medicine, Medical Clinic 1, University of Padua, Padua, Italy.
Andrea GiustiUnit of Rheumatology, ASL3-Liguria Region, Genoa, Italy.
Claudio MarcocciDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Stefano GonnelliDepartment of Medicine, Surgery and Neuroscience, Le Scotte University Hospital, University of Siena, Siena, Italy.
Gian Carlo IsaiaDepartment of Medical Science, Section of Gerontology and Bone Metabolic Disease, University of Turin, Turin, Italy.
Maurizio RossiniDepartment of Medicine, Rheumatology Unit, University of Verona, Verona, Italy.
Iacopo ChiodiniUnit for Bone Metabolism Disease and Diabetes and Lab of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Via Magnasco 2, 20149, Milan, Italy. iacopo.chiodini@unimi.it.ORCID http://orcid.org/0000-0001-7594-3300
Marco Di StefanoDepartment of Medical Science, Section of Gerontology and Bone Metabolic Disease, University of Turin, Turin, Italy.
Italian Society for Osteoporosis, Mineral Metabolism, Skeletal Diseases (SIOMMMS)
Royal Osteoporosis Society · GBUniversity of Milan · ITRegione LiguriaUniversity of Turin · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITForo Italico University of Rome · ITIRCCS Istituto Auxologico Italiano · ITUniversity of Padua · ITUniversity of Pisa · ITUniversity of Siena · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA low calcium intake is a well-known factor that influences the bone mineral density (BMD) maintenance. In the presence of inadequate calcium intake, secondary hyperparathyroidism develops, leading to an increased bone turnover and fracture risk.

aimsTo assess the dietary calcium intake in relation with osteoporosis and fragility fracture in a cohort of Italian individuals evaluated for low BMD.

methodsA 7-day food-frequency questionnaire was administered to 1793 individuals, who were consecutively referred at the Centers of the Italian Society for Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS) for low BMD.

resultsIn 30.3% and 20.9% of subjects, the calcium intake was inadequate (< 700 mg/day) and adequate (> 1200 mg/day), respectively. As compared with patients with adequate calcium intake, those with inadequate calcium intake were younger (65.5 ± 10.8 vs 63.9 ± 11.5 years, p = 0.03) and they more frequently reported adverse reactions to food (3.2% vs 7.2% p = 0.01) and previous major fragility fractures (20.8% vs 27.0%, p = 0.03). Patients with calcium intake < 700 mg/day showed a higher prevalence of diabetes mellitus, idiopathic hypercalciuria and food allergy/intolerance (8.1%, 5.1%, 7.2%, respectively) than patients with calcium intake > 700 mg/day (5.3%, 3.0%, 4.1%, respectively, p < 0.04 for all comparisons), also after adjusting for age, gender and body mass index. In 30.3% of fractured subjects, the calcium intake was < 700 mg/day. DISCUSSION: In Italy, a low calcium intake is highly prevalent in individuals at risk for low BMD. Importantly, an inadequate calcium intake is highly prevalent even in patients with history of fragility fractures.

conclusionsOnly about a fifth of patients being assessed for low BMD in an Italian SIOMMMS referral Centre have an adequate calcium intake.

Indexed as

Bone Diseases, MetabolicFractures, BoneOsteoporosisBone DensityCalcium, DietaryHumansItalyCalcium, DietaryBone mineral densityDietary calcium intakeFracturesOsteoporosis

Identifiers

PMID33909280
PMCPMC8668846
OpenAlexW3157829296

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.