Evidence map›Paper›PMID 33909192›Full record

ArticleAnnals of biomedical engineering2021

Towards Transabdominal Functional Photoacoustic Imaging of the Placenta: Improvement in Imaging Depth Through Optimization of Light Delivery.

Kristie Huda, Kenneth F Swan, Cecilia T Gambala, Gabriella C Pridjian, Carolyn L Bayer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Depth-dependent fluence compensation withoutJournal of biomedical optics · 2025
    Article
  4. Article
  5. Functional Photoacoustic Imaging for Placental Monitoring: A Mini Review.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kristie HudaDepartment of Biomedical Engineering, Tulane University, 500 Lindy Boggs Center, New Orleans, LA, 70118, USA.
Kenneth F SwanDepartment of Obstetrics and Gynecology, Tulane University, 1430 Tulane Ave, New Orleans, LA, 70112, USA.
Cecilia T GambalaSchool of Medicine, Tulane University, 1430 Tulane Ave, New Orleans, LA, 70112, USA.
Gabriella C PridjianDepartment of Obstetrics and Gynecology, Tulane University, 1430 Tulane Ave, New Orleans, LA, 70112, USA.
Carolyn L BayerDepartment of Biomedical Engineering, Tulane University, 500 Lindy Boggs Center, New Orleans, LA, 70118, USA. carolynb@tulane.edu.ORCID http://orcid.org/0000-0003-0947-6892
Tulane University · US

Funding

Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Katherine Teresa Mills · 2016 to 2026
$25.3M
Placental Functional Imaging to Predict Preeclampsia Therapeutic OutcomesR01HD097466 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI BAYER, CAROLYN LOUISE · 2019 to 2023
$1.6M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD097466NICHD NIH HHS R01 HD097466NIGMS NIH HHS P20 GM109036NIGMS NIH HHS P20GM109036
6 · The paper itself

Abstract

Functional photoacoustic imaging of the placenta could provide an innovative tool to diagnose preeclampsia, monitor fetal growth restriction, and determine the developmental impacts of gestational diabetes. However, transabdominal photoacoustic imaging is limited in imaging depth due to the tissue's scattering and absorption of light. The aim of this paper was to investigate the impact of geometry and wavelength on transabdominal light delivery. Our methods included the development of a multilayer model of the abdominal tissue and simulation of the light propagation using Monte Carlo methods. A bifurcated light source with varying incident angle of light, distance between light beams, and beam area was simulated to analyze the effect of light delivery geometry on the fluence distribution at depth. The impact of wavelength and the effects of variable thicknesses of adipose tissue and muscle were also studied. Our results showed that the beam area plays a major role in improving the delivery of light to deep tissue, in comparison to light incidence angle or distance between the bifurcated fibers. Longer wavelengths, with incident fluence at the maximum permissible exposure limit, also increases fluence within deeper tissue. We validated our simulations using a commercially available light delivery system and ex vivo human placental tissue. Additionally, we compared our optimized light delivery to a commercially available light delivery system, and conclude that our optimized geometry could improve imaging depth more than 1.6×, bringing the imaging depth to within the needed range for transabdominal imaging of the human placenta.

Indexed as

Computer SimulationModels, BiologicalFemaleHumansMonte Carlo MethodPhantoms, ImagingPhotoacoustic TechniquesPlacentaPregnancyMonte Carlo simulationPhotoacoustic imagingPlacentaTransabdominal imaging

Identifiers

PMID33909192
PMCPMC8373763
OpenAlexW3158345717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.