Evidence map›Paper›PMID 33909147›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

Prevalence and correlates of cancer-related fatigue in breast cancer survivors.

Alejandro Álvarez-Bustos, Cristina G de Pedro, María Romero-Elías, Javier Ramos, Pablo Osorio, Blanca Cantos, Constanza Maximiano, Miriam Méndez, Carmen Fiuza-Luces, Marta Méndez-Otero and 3 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  3. Impact of resistance training on fatigue among breast cancer patients undergoing chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  8. Article
  9. Symptom burden in cancer survivorship: insights from a survivorship program's patient-reported outcomes database.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
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  10. Post-treatment adaptation experiences of women breast cancer survivors: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  20. Correlates of cancer-related fatigue in colorectal cancer patients at the time of diagnosis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Alejandro Álvarez-BustosDepartment of Medical Oncology, Hospital Universitario Puerta de Hierro-Majadahonda, 28220, Madrid, Spain.
Cristina G de PedroDepartment of Medical Oncology, Hospital Universitario Puerta de Hierro-Majadahonda, 28220, Madrid, Spain.
María Romero-ElíasDepartment of Sports Sciences, Universidad Miguel Hernández de Elche, Av. De la Universidad s/n, 03202 Elche, Alicante, Spain.
Javier RamosDepartment of Medical Oncology, Hospital Universitario Puerta de Hierro-Majadahonda, 28220, Madrid, Spain.
Pablo OsorioDepartment of Medical Oncology, Hospital Universitario Puerta de Hierro-Majadahonda, 28220, Madrid, Spain.
Blanca CantosDepartment of Medical Oncology, Hospital Universitario Puerta de Hierro-Majadahonda, 28220, Madrid, Spain.
Constanza MaximianoDepartment of Medical Oncology, Hospital Universitario Puerta de Hierro-Majadahonda, 28220, Madrid, Spain.
Miriam MéndezDepartment of Medical Oncology, Hospital Universitario Puerta de Hierro-Majadahonda, 28220, Madrid, Spain.
Carmen Fiuza-LucesInstituto de Investigación Doce de Octubre, Avda Cordoba sn, 28041, Madrid, Spain.
Marta Méndez-OteroDepartment of Medical Oncology, Hospital Universitario Puerta de Hierro-Majadahonda, 28220, Madrid, Spain.
Silvia MartínDepartment of Medical Oncology, Hospital Universitario Puerta de Hierro-Majadahonda, 28220, Madrid, Spain.
Héctor CebollaUniversidad Nacional Española a Distancia, Madrid, Spain.
Ana Ruiz-CasadoDepartment of Medical Oncology, Hospital Universitario Puerta de Hierro-Majadahonda, 28220, Madrid, Spain. arcasado@salud.madrid.org.ORCID http://orcid.org/0000-0002-7672-2638
Hospital Universitario Puerta de Hierro Majadahonda · ESResearch Institute Hospital 12 de Octubre · ESUniversidad Nacional de Educación a Distancia · ESUniversitat de Miguel Hernández d'Elx · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo identify potential correlates of cancer-related fatigue (CRF) after curative breast cancer (BC) treatment. The hypothesis was that fatigue would be more severe among women treated with cardiotoxic drugs, with poor physical condition and those who exercised less.

methodsObservational cross-sectional design. Fatigue was evaluated through PERFORM Questionnaire (multi-item, multi-dimensional). Patient-reported assessments and objective information regarding clinical data, physical activity (PA) and physical condition were analysed as potential correlates of CRF.

resultsOne hundred eighty women who remained free of disease were recruited. The prevalence of fatigue interfering with quality of life was 43%. Weight, resting and recovery heart rate were positively associated with fatigue. Age and time from diagnosis were negatively associated. Previous therapies, objectively assessed weekly PA, cardiorespiratory condition, muscular strength and adherence to Mediterranean diet were not associated with CRF.

conclusionsCRF is a prevalent problem after BC treatment. Objectively assessed PA, cardiorespiratory fitness and muscular strength did not predict CRF. The association of heart rate and fatigue deserves a further insight. Future research should include longitudinal studies and determination of biomarkers. IMPLICATIONS FOR CANCER SURVIVORS: BC survivors, especially younger and overweight women, should be informed about fatigue as a potential persistent symptom through all stages of the cancer trajectory and into survivorship. They also should be routinely screened for CRF.

Indexed as

Breast NeoplasmsCancer SurvivorsCross-Sectional StudiesFatigueFemaleHumansPrevalenceQuality of LifeSurvivorsBreast cancerCancer-related fatigueCancer survivorsCardiorespiratory fitnessHeart ratePhysical activity

Identifiers

PMID33909147
OpenAlexW3127680893

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.