Evidence map›Paper›PMID 33908965›Full record

ArticleNanoscale2021

Mechanochemical properties of DNA origami nanosprings revealed by force jumps in optical tweezers.

Deepak Karna, Wei Pan, Shankar Pandey, Yuki Suzuki, Hanbin Mao

Open access · greenAbstract read
In one paragraph

Article in Nanoscale, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. DNA origami nano-mechanics.Chemical Society reviews · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Deepak KarnaDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, USA. hmao@kent.edu.
Wei Pan
Shankar Pandey
Yuki Suzuki
Hanbin Mao
Kent State University · USSendai University · JP

Funding

Specific Recognition of G-quadruplexesR01CA236350 · NCI · KENT STATE UNIVERSITY · PI MAO, HANBIN · 2018 to 2022
$1.6M
NCI NIH HHS R01 CA236350
6 · The paper itself

Abstract

By incorporating pH responsive i-motif elements, we have constructed DNA origami nanosprings that respond to pH changes in the environment. Using an innovative force jump approach in optical tweezers, we have directly measured the spring constants and dynamic recoiling responses of the DNA nanosprings under different forces. These DNA nanosprings exhibited 3 times slower recoiling rates compared to duplex DNA backbones. In addition, we observed two distinct force regions which show different spring constants. In the entropic region below 2 pN, a spring constant of ∼0.03 pN nm

Indexed as

DNAOptical TweezersDNA

Identifiers

PMID33908965
PMCPMC8170849
OpenAlexW3153791384

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.