ArticleeLife2021
Common virulence gene expression in adult first-time infected malaria patients and severe cases.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- RNA-seq research landscape in Africa: systematic review reveals disparities and opportunities.European journal of medical research · 2023Pooled it
- The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections.PLoS pathogens · 2023Trial
- Predictive value of PfEMP1 antibody profiles for the course of controlled human malaria infections.PLoS pathogens · 2026Article
- Genome-wide analysis of strand-specific transcription and DNA methylation inFrontiers in microbiology · 2026Article
- TargetingFrontiers in microbiology · 2026Review
- Article
- Plasmodium falciparum expresses fewer var genes at lower levels during asymptomatic dry season infections than clinical malaria cases.PLoS pathogens · 2025Article
- Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype.PLoS pathogens · 2025Article
- PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adults.EBioMedicine · 2024Article
- Machine learning prediction of malaria vaccine efficacy based on antibody profiles.PLoS computational biology · 2024Article
- The malarial blood transcriptome: translational applications.Biochemical Society transactions · 2024Review
- A novel computational pipeline foreLife · 2024Article
- PfEMP1 and var genes - Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity.Advances in parasitology · 2024Review
- Review
- The Kelch13 compartment contains highly divergent vesicle trafficking proteins in malaria parasites.PLoS pathogens · 2023Article
- Pathogenetic mechanisms and treatment targets in cerebral malaria.Nature reviews. Neurology · 2023Review
- Antibody to Plasmodium falciparum Variant Surface Antigens, var Gene Transcription, and ABO Blood Group in Children With Severe or Uncomplicated Malaria.The Journal of infectious diseases · 2023Article
- CD36-A Host Receptor Necessary for Malaria Parasites to Establish and Maintain Infection.Microorganisms · 2022Review
- Transcriptome Analysis of Plasmodium falciparum Isolates From Benin Reveals Specific Gene Expression Associated With Cerebral Malaria.The Journal of infectious diseases · 2022Article
- Varia: a tool for prediction, analysis and visualisation of variable genes.BMC bioinformatics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 8 institutions in 4 countries.
J Stephan WichersMolecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.ORCID 0000-0002-0599-1742
Gerry Tonkin-HillWellcome Sanger Institute, Hinxton, United Kingdom.ORCID 0000-0003-4397-2224
Thorsten ThyeEpidemiology and Diagnostics, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.ORCID 0000-0002-8720-7113
Ralf KrumkampEpidemiology and Diagnostics, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.ORCID 0000-0003-3053-476X
Benno KreuelsDepartment of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Germany, Hamburg, Germany.ORCID 0000-0003-2315-8954
Jan StraussMolecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.ORCID 0000-0002-6208-791X
Heidrun von ThienMolecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Judith Am ScholzMolecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Helle Smedegaard HanssonCMP, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-6484-1165
Rasmus Weisel JensenCMP, University of Copenhagen, Copenhagen, Denmark.
Louise TurnerCMP, University of Copenhagen, Copenhagen, Denmark.
Freia-Raphaella LorenzInstitute of Tropical Medicine, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-7401-2720
Anna SchöllhornInstitute of Tropical Medicine, University of Tübingen, Tübingen, Germany.ORCID 0000-0001-7928-7312
Iris BruchhausMolecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.ORCID 0000-0002-3363-7409
Egbert TannichEpidemiology and Diagnostics, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.ORCID 0000-0002-4714-7275
Rolf FendelInstitute of Tropical Medicine, University of Tübingen, Tübingen, Germany.ORCID 0000-0003-4716-0311
Thomas D OttoInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0002-1246-7404
Thomas LavstsenCMP, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3044-4249
Tim W GilbergerMolecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.ORCID 0000-0002-7965-8272
Michael F DuffyDepartment of Microbiology and Immunology, University of Melbourne, Melbourne, Australia.
Anna BachmannMolecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.ORCID 0000-0001-8397-7308
Universität Hamburg · DEUniversity of Copenhagen · DKGerman Center for Infection Research · DEBernhard Nocht Institute for Tropical Medicine · DEUniversity of Tübingen · DEThe University of Melbourne · AUUniversity of Glasgow · GBWellcome Sanger Institute · GB
Funding
Wellcome TrustWellcome Trust 104111/Z/14/ZR
Abstract
Sequestration of
Indexed as
AdultCD36 AntigensCohort StudiesEndothelial Protein C ReceptorFemaleHumansMalaria, FalciparumMalePlasmodium falciparumProtein BindingProtozoan ProteinsYoung AdultCD36 AntigensEndothelial Protein C Receptorerythrocyte membrane protein 1, Plasmodium falciparumProtozoan Proteinschromosomesgene expressioninfectious diseasemicrobiologyP. falciparumPfEMP1RNA-seqtranscriptomicsvariant surface antigensvirulence
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.