Evidence map›Paper›PMID 33908695›Full record

ArticleChemMedChem2021

Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates.

Ana G Enderle, Matteo Bosso, Rüdiger Groß, Magdalena Heiland, Mariela Bollini, María J Culzoni, Frank Kirchhoff, Jan Münch, Carsten Streb

Open access · hybridAbstract read
In one paragraph

Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Polyoxometalates Impact as Anticancer Agents.International journal of molecular sciences · 2023
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ana G EnderleInstitute of Inorganic Chemistry I, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
Matteo BossoInstitute of Molecular Virology, Ulm University Medical Center, Meyerhofstraße 1, 89081, Ulm, Germany.
Rüdiger GroßInstitute of Molecular Virology, Ulm University Medical Center, Meyerhofstraße 1, 89081, Ulm, Germany.
Magdalena HeilandInstitute of Inorganic Chemistry I, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
Mariela BolliniMedicinal Chemistry Lab, Centro de Investigaciones en Bionanociencias (CIBION), CONICET, Godoy Cruz, 2390, C1425FQD, Ciudad de Buenos Aires, Argentina.
María J CulzoniLaboratorio de Desarrollo Analítico y Quimiometría (LADAQ), Universidad Nacional del Litoral - CONICET, Ciudad Universitaria, Paraje El Pozo, CC242, S3000, Santa Fe, Argentina.
Frank KirchhoffInstitute of Molecular Virology, Ulm University Medical Center, Meyerhofstraße 1, 89081, Ulm, Germany.
Jan MünchInstitute of Molecular Virology, Ulm University Medical Center, Meyerhofstraße 1, 89081, Ulm, Germany.
Carsten StrebInstitute of Inorganic Chemistry I, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.ORCID 0000-0002-5846-1905
Consejo Nacional de Investigaciones Científicas y Técnicas · ARUniversität Ulm · DE

Funding

Agencia Nacional de Promoción Científica y Tecnológica, Argentina 2017-0340Agencia Nacional de Promoción Científica y Tecnológica, Argentina 2017-3767Deutsche Forschungsgemeinschaft (DFG)DFG CRC 1279Ulm University
6 · The paper itself

Abstract

Polyoxometalates (POMs), molecular metal oxide anions, are inorganic clusters with promising antiviral activity. Herein we report increased anti-HIV-1 activity of a POM when electrostatically combined with organic counter-cations. To this end, Keggin-type cerium tungstate POMs have been combined with organic methyl-caffeinium (Caf) cations, and their cytotoxicity, antiviral activity and mode of action have been studied. The novel compound, Caf

Indexed as

AnionsAnti-HIV AgentsCaffeineDose-Response Relationship, DrugHIVMicrobial Sensitivity TestsPolyelectrolytesPolyoxometalatesAnionsAnti-HIV AgentsCaffeinePolyelectrolytesPolyoxometalatesAntiviral ActivityCationsHIVPolyoxometalatesSelf-Assembly

Identifiers

PMID33908695
PMCPMC8518980
OpenAlexW3158957759

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.