ArticleThe Journal of comparative neurology2021
The synaptic inputs and thalamic projections of two classes of layer 6 corticothalamic neurons in primary somatosensory cortex of the mouse.
Article in The Journal of comparative neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Deviance detection via competitive inhibition between local neocortical ensembles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Electrical Coupling within Thalamocortical Networks Cumulatively Reduces Cortical Correlation to Sensory Inputs.eNeuro · 2026Article
- Corticothalamic layer 6 controls cortical activity and thalamic firing mode in a bidirectional manner.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Cell-type-selective synaptogenesis during the development of layer 6 corticothalamic neuron connectivity in the mammalian neocortex.Cell reports · 2026Article
- Somatosensory control of thalamic relay neurons is regulated by two distinct layer 6 feedback systems.iScience · 2026Article
- A consensus definition for deep layer 6 excitatory neurons in mouse somatosensory, visual, and motor cortex.Cell reports · 2025Article
- Deviance detection via competitive inhibition between local neocortical ensembles.bioRxiv : the preprint server for biology · 2025Article
- Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice.Cell reports · 2025Article
- Complementary Organization of Mouse Driver and Modulator Cortico-thalamo-cortical Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems.iScience · 2025Article
- Software and pipelines for registration and analyses of rodent brain image data in reference atlas space.Frontiers in neuroinformatics · 2025Article
- Article
- Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits.bioRxiv : the preprint server for biology · 2024Article
- Functionally Distinct Circuits Are Linked by Heterocellular Electrical Synapses in the Thalamic Reticular Nucleus.eNeuro · 2024Article
- DeepSlice: rapid fully automatic registration of mouse brain imaging to a volumetric atlas.Nature communications · 2023Article
- Structure and function of neocortical layer 6b.Frontiers in cellular neuroscience · 2023Review
- Design and evaluation of a rodent-specific focal transcranial magnetic stimulation coil with the custom shielding application in rats.Frontiers in neuroscience · 2023Article
- Layer 5 of cortex innervates the thalamic reticular nucleus in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Thalamic subnetworks as units of function.Nature neuroscience · 2022Review
- Corticothalamic Pathways From Layer 5: Emerging Roles in Computation and Pathology.Frontiers in neural circuits · 2021Review
Corrections and comments
- Erratum issuedErratum.2022
Authors and funding
4 authors.
Funding
Abstract
Although corticothalamic neurons (CThNs) represent the largest source of synaptic input to thalamic neurons, their role in regulating thalamocortical interactions remains incompletely understood. CThNs in sensory cortex have historically been divided into two types, those with cell bodies in Layer 6 (L6) that project back to primary sensory thalamic nuclei and those with cell bodies in Layer 5 (L5) that project to higher-order thalamic nuclei and subcortical structures. Recently, diversity among L6 CThNs has increasingly been appreciated. In the rodent somatosensory cortex, two major classes of L6 CThNs have been identified: one projecting to the ventral posterior medial nucleus (VPM-only L6 CThNs) and one projecting to both VPM and the posterior medial nucleus (VPM/POm L6 CThNs). Using rabies-based tracing methods in mice, we asked whether these L6 CThN populations integrate similar synaptic inputs. We found that both types of L6 CThNs received local input from somatosensory cortex and thalamic input from VPM and POm. However, VPM/POm L6 CThNs received significantly more input from a number of additional cortical areas, higher order thalamic nuclei, and subcortical structures. We also found that the two types of L6 CThNs target different functional regions within the thalamic reticular nucleus (TRN). Together, our results indicate that these two types of L6 CThNs represent distinct information streams in the somatosensory cortex and suggest that VPM-only L6 CThNs regulate, via their more restricted circuits, sensory responses related to a cortical column while VPM/POm L6 CThNs, which are integrated into more widespread POm-related circuits, relay contextual information.
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