ArticlePathogens and disease2021
Virulence potential of Rickettsia amblyommatis for spotted fever pathogenesis in mice.
Article in Pathogens and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- It takes a village: Community science informs tick encounter, pathogen, and exposure risk in North Carolina, USA.PloS one · 2026Article
- High seroprevalence of Rickettsia spp. and molecular detection of Rickettsia amblyommatis in human-biting ticks from the eastern Amazon, Brazil.Parasites & vectors · 2025Article
- Distribution ofParasite epidemiology and control · 2025Review
- Characterization of Transstadial Transmission of Rickettsia Amblyommatis in Haemaphysalis Longicornis Using Optimized Artificial Membrane Feeding System.The American journal of tropical medicine and hygiene · 2025Article
- The bacterial diversity and potential pathogenic risks of giant panda-infesting ticks.Microbiology spectrum · 2025Article
- Bird-tick and human-tick encounters in the Rio Grande Valley (Texas, USA): ecological associations and pathogen detections.Parasites & vectors · 2025Article
- Surveillance of tick-borne pathogens present in ticks (Acari: Ixodidae) removed from companion animals in Louisiana, USA.Journal of medical entomology · 2025Article
- Optimization of artificial membrane feeding system for lone star ticks, Amblyomma americanum (Acari: Ixodidae), and experimental infection with Rickettsia amblyommatis (Rickettsiales: Rickettsiaceae).Journal of medical entomology · 2024Article
- Spotted Fever GroupInsects · 2024Review
- Microbiome of Invasive Tick SpeciesInsects · 2024Article
- Eco-epidemiology of Rickettsia amblyommatis and Rickettsia parkeri in naturally infected ticks (Acari: Ixodida) from South Carolina.Parasites & vectors · 2024Article
- Tick-Borne Co-Infections: Challenges in Molecular and Serologic Diagnoses.Pathogens (Basel, Switzerland) · 2023Review
- First isolation of Rickettsia amblyommatis from Amblyomma mixtum in Colombia.Parasites & vectors · 2023Article
- Detection of Rickettsia amblyommatis and Rickettsia bellii in ticks collected from pet dogs in peri-urban and rural areas in Yucatan, Mexico.Experimental & applied acarology · 2023Article
- Review
- A story of a lone star tick: an imported case of Amblyomma americanum (Linnaeus, 1758) infected with Rickettsia amblyommatis that parasitized a US traveler returning to Mexico.Revista do Instituto de Medicina Tropical de Sao Paulo · 2023Article
- Review
- Brown Dog Tick (International journal of environmental research and public health · 2022Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Rickettsia amblyommatis belongs to the spotted fever group of Rickettsia and infects Amblyomma americanum (Lone Star ticks) for transmission to offspring and mammals. Historically, the geographic range of A. americanum was restricted to the southeastern USA. However, recent tick surveys identified the progressive northward invasion of A. americanum, contributing to the increased number of patients with febrile illnesses of unknown etiology after a tick bite in the northeastern USA. While serological evidence strongly suggests that patients are infected with R. amblyommatis, the virulence potential of R. amblyommatis is not well established. Here, we performed a bioinformatic analysis of three genome sequences of R. amblyommatis and identified the presence of multiple putative virulence genes whose products are implicated for spotted fever pathogenesis. Similar to other pathogenic spotted fever rickettsiae, R. amblyommatis replicated intracellularly within the cytoplasm of tissue culture cells. Interestingly, R. amblyommatis displayed defective attachment to microvascular endothelial cells. The attachment defect and slow growth rate of R. amblyommatis required relatively high intravenous infectious doses to produce dose-dependent morbidity and mortality in C3H mice. In summary, our results corroborate clinical evidence that R. amblyommatis can cause mild disease manifestation in some patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.