Evidence map›Paper›PMID 33908526›Full record

ReviewChemical Society reviews2021

Biosynthesis and synthetic biology of psychoactive natural products.

Cooper S Jamieson, Joshua Misa, Yi Tang, John M Billingsley

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chemical Society reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  14. Evolution of the biochemistry underpinning purine alkaloid metabolism in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  15. Polyphenolic Platform Ameliorated Sanshool for Skin Photoprotection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cooper S JamiesonDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA. yitang@ucla.edu.ORCID http://orcid.org/0000-0002-6076-6230
Joshua MisaDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA. johnbillingsley@ucla.edu.ORCID http://orcid.org/0000-0002-3722-8573
Yi TangDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA. yitang@ucla.edu and Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA. johnbillingsley@ucla.edu.ORCID http://orcid.org/0000-0003-1597-0141
John M BillingsleyDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA. johnbillingsley@ucla.edu and Invizyne Technologies, Inc., Monrovia, CA, USA.ORCID http://orcid.org/0000-0001-9300-9378

Funding

Engineering Yeast towards High Titer Production of Monoterpene Indole Alkaloid Natural ProductsR01AT010001 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Dino Di Carlo, Yi Tang · 2018 to 2026
$3.6M
Chemistry Biology Interface Training ProgramT32GM136614 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Patrick G. Harran · 2020 to 2026
$2.8M
NCCIH NIH HHS R01 AT010001NIGMS NIH HHS T32 GM136614
6 · The paper itself

Abstract

Psychoactive natural products play an integral role in the modern world. The tremendous structural complexity displayed by such molecules confers diverse biological activities of significant medicinal value and sociocultural impact. Accordingly, in the last two centuries, immense effort has been devoted towards establishing how plants, animals, and fungi synthesize complex natural products from simple metabolic precursors. The recent explosion of genomics data and molecular biology tools has enabled the identification of genes encoding proteins that catalyze individual biosynthetic steps. Once fully elucidated, the "biosynthetic pathways" are often comparable to organic syntheses in elegance and yield. Additionally, the discovery of biosynthetic enzymes provides powerful catalysts which may be repurposed for synthetic biology applications, or implemented with chemoenzymatic synthetic approaches. In this review, we discuss the progress that has been made toward biosynthetic pathway elucidation amongst four classes of psychoactive natural products: hallucinogens, stimulants, cannabinoids, and opioids. Compounds of diverse biosynthetic origin - terpene, amino acid, polyketide - are identified, and notable mechanisms of key scaffold transforming steps are highlighted. We also provide a description of subsequent applications of the biosynthetic machinery, with an emphasis placed on the synthetic biology and metabolic engineering strategies enabling heterologous production.

Indexed as

Biological ProductsMolecular StructurePsychotropic DrugsBiological ProductsPsychotropic Drugs

Identifiers

PMID33908526
PMCPMC8217322

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.