ArticleCancer cytopathology2021
Accuracy of parotid gland FNA cytology and reliability of the Milan System for Reporting Salivary Gland Cytopathology in clinical practice.
Article in Cancer cytopathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 36 citations in OpenAlex.
- Preoperatively Diagnosed Versus Undiagnosed Major Salivary Gland Cancer: Clinicopathological Characteristics, Treatment Strategies, and Oncological Outcomes.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Cytopathology Terminology Systems: European Federation of Cytological Societies Survey on Practice in Europe.Cytopathology : official journal of the British Society for Clinical Cytology · 2026Article
- Optimizing preoperative assessment of salivary gland lesions: updates and practical implications in the Milan System 2nd edition.Virchows Archiv : an international journal of pathology · 2026Review
- Contemporary Management of Malignancies of the Parotid Gland: A State-of-the-Art Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Review
- Fine-needle aspiration cytology reduces the frequency of surgeries for malignant salivary gland tumors.Cancer cytopathology · 2026Article
- Using Machine Learning on MRI Radiomics to Diagnose Parotid Tumours Before Comparing Performance with Radiologists: A Pilot Study.Journal of imaging informatics in medicine · 2025Article
- Development and evaluation of a clinical-biochemical nomogram for differentiating pleomorphic adenoma and Warthin's tumor in the parotid gland.Frontiers in oncology · 2025Article
- The Impact of Inflammation on the Etiopathogenesis of Benign Salivary Gland Tumors: A Scoping Review.International journal of molecular sciences · 2024Article
- Deep learning-assisted diagnosis of benign and malignant parotid tumors based on ultrasound: a retrospective study.BMC cancer · 2024Article
- The Usefulness of Fine Needle Aspiration Cytology in the Management of Parotid Gland Masses at a Tertiary Academic Hospital.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Article
- The Milan system for reporting salivary gland cytopathology-A single-center study of 2156 cases.Cancer medicine · 2023Article
- Value of cytopathology in the diagnosis of adenoid cystic carcinoma and an analysis of misdiagnoses.BMC surgery · 2023Article
- Nondiagnostic category of Milan System for Reporting Pediatric Salivary Gland Cytopathology: outcomes and root cause analysis.Cancer cytopathology · 2022Article
- Validation of the Milan System for Reporting Salivary Gland Cytopathology and the diagnostic accuracy of FNA cytology for submandibular gland lesions.Cancer cytopathology · 2022Article
- Accuracy of parotid gland FNA cytology and reliability of the Milan System for Reporting Salivary Gland Cytopathology in clinical practice.Cancer cytopathology · 2021Article
- Salivary gland fine-needle aspiration biopsy: quality assurance results from a tertiary cancer center.Journal of the American Society of CytopathologyArticle
- The Second Edition of the Milan System for Reporting Salivary Gland Cytopathology: System Application, Outcome, and Cytohistological Correlation.Journal of cytologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferentiating between malignant and benign salivary gland tumors with fine-needle aspiration cytology (FNAC) can be challenging. This study was aimed at testing the validity of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) and at assessing possible differences in the sensitivity and specificity of parotid gland FNAC between dedicated head and neck (H&N) centers, subdivided into head and neck oncology centers (HNOCs) and head and neck oncology affiliated centers (HNOACs), and general hospitals (GHs).
methodsThe Dutch Pathology Registry (PALGA) database was searched for patients who had undergone a salivary gland resection between January 1, 2006, and January 1, 2017, and had a preoperative FNAC result. The FNAC reports were retrospectively assigned to MSRSGC categories. The risk of malignancy (ROM) was calculated for each category. The sensitivity and specificity for diagnosing malignancy were calculated and compared among HNOCs, HNOACs, and GHs.
resultsIn all, 12,898 FNAC aspirates were evaluated. The ROMs for each category were as follows: 12.5% in MSRSGC I, 10.3% in MSRSGC II, 29% in MSRSGC III, 2.3% in MSRSGC IVa, 28.6% in MSRSGC IVb, 83% in MSRSGC V, and 99.3% in MSRSGC VI. The sensitivity of FNAC was highest in HNOCs (88.1%), HNOACs scored lower (79.7%), and GHs had a sensitivity of 75.0%.
conclusionsThe MSRSGC is a valid tool for reporting parotid gland FNAC; therefore, these results strongly advocate its use. On the basis of the higher sensitivity of FNAC in dedicated H&N centers, the authors recommend that GHs use the presented management strategies to help to minimize the chances of a preoperative misdiagnosis.
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