Evidence map›Paper›PMID 33907987›Full record

ArticleDrug delivery and translational research2022

Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO

Weizhi Xu, Zonglan Zhao, James Falconer, Andrew K Whittaker, Amirali Popat, Maree T Smith, Tushar Kumeria, Felicity Y Han

Abstract read
PubMed Publisher
In one paragraph

Article in Drug delivery and translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Weizhi XuSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Zonglan ZhaoSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
James FalconerSchool of Pharmacy, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane, QLD, Australia.
Andrew K WhittakerAustralia Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
Amirali PopatSchool of Pharmacy, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane, QLD, Australia.
Maree T SmithSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-2281-3734
Tushar KumeriaSchool of Pharmacy, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane, QLD, Australia. t.kumeria@unsw.edu.au.
Felicity Y HanSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. f.han@uq.edu.au.ORCID http://orcid.org/0000-0001-7260-5832
The University of Queensland · AUTranslational Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ketamine in sub-anaesthetic doses has analgesic properties and an opioid-sparing effect. Intrathecal (i.t.) delivery of analgesics bypasses systemic metabolism and delivers the analgesic agent adjacent to the target receptors in the spinal cord and so small doses are required to achieve effective pain relief. In order to relieve intractable cancer-related pain, sustained-release ketamine formulations are required in combination with a strong opioid because frequent i.t. injection is not practical. In this study, ketamine or ketamine-loaded porous silicon (pSi) were encapsulated into poly(lactic-co-glycolic acid) (PLGA) microparticles by a novel supercritical carbon dioxide (scCO

Indexed as

KetamineAnalgesicsAnalgesics, OpioidCarbon DioxideDelayed-Action PreparationsParticle SizePolylactic Acid-Polyglycolic Acid CopolymerPorositySiliconSolventsAnalgesicsAnalgesics, OpioidCarbon DioxideDelayed-Action PreparationsKetaminePolylactic Acid-Polyglycolic Acid CopolymerSiliconSolventsCancer-related painDrug delivery systemHigher encapsulation efficiency (EE)PLGA typeSize of scCO2 vessel

Identifiers

PMID33907987
OpenAlexW3158723345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.