Evidence map›Paper›PMID 33907963›Full record

SynthesisJournal of molecular neuroscience : MN2021

Protective Effects of Nicotinamide Adenine Dinucleotide and Related Precursors in Alzheimer's Disease: A Systematic Review of Preclinical Studies.

Leila Hosseini, Javad Mahmoudi, Fariba Pashazadeh, Hanieh Salehi-Pourmehr, Saeed Sadigh-Eteghad

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. In defence of ferroptosis.Signal transduction and targeted therapy · 2025
    Review
  4. Review
  5. Review
  6. Mitochondria in Alzheimer's Disease Pathogenesis.Life (Basel, Switzerland) · 2024
    Review
  7. Review
  8. Supplementation with NADNutrients · 2022
    Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Leila HosseiniNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Javad MahmoudiNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Fariba PashazadehResearch Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Hanieh Salehi-PourmehrResearch Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Saeed Sadigh-EteghadNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Saeed.sadigetegad@gmail.com.ORCID http://orcid.org/0000-0003-2872-1072
Tabriz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data from preclinical studies propose nicotinamide adenine dinucleotide (NAD

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsAnti-Inflammatory AgentsApoptosisBehavior, AnimalDisease Models, AnimalDrug Evaluation, PreclinicalEnergy MetabolismMiceMice, TransgenicMitochondriaNADNeuroinflammatory DiseasesNeuroprotective AgentsNiacinAmyloid beta-PeptidesAnti-Inflammatory AgentsNADNeuroprotective AgentsNiacinNiacinamidetau ProteinsAlzheimer’s diseaseCognitionNeuroprotectionNicotinamideRodent

Identifiers

PMID33907963
OpenAlexW3159794395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.