Evidence map›Paper›PMID 33907817›Full record

ArticleInternational journal of molecular medicine2021

Silencing microRNA‑29b‑3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway.

Heting Liu, Yanghui Xiu, Qing Zhang, Yuxin Xu, Qianqian Wan, Liming Tao

Open access · hybridAbstract read
In one paragraph

Article in International journal of molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  8. Review
  9. The role of microRNAs in glaucoma.Experimental eye research · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Heting LiuDepartment of Ophthalmology, The Second Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China.
Yanghui XiuEye Institute and Xiamen Eye Center, Affiliated Xiamen University, Xiamen, Fujian 361000, P.R. China.
Qing ZhangDepartment of Ophthalmology, The Second Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China.
Yuxin XuDepartment of Ophthalmology, The Second Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China.
Qianqian WanDepartment of Ophthalmology, The Second Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China.
Liming TaoDepartment of Ophthalmology, The Second Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China.
Second Hospital of Anhui Medical University · CNAnhui Medical University · CNXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the potential involvement of numerous microRNAs (miRNAs) in glaucoma has been widely reported. However, the role of microRNA‑29b‑3p (miR‑29b‑3p) in the pathogenesis of glaucoma remains unknown. This study aimed to explore the biological role and regulatory mechanism of miR‑29b‑3p in the oxidative injury of human trabecular meshwork (HTM) cells induced by H

Indexed as

Gene SilencingMAP Kinase Signaling SystemOxidative StressAnimalsBase SequenceDisease Models, AnimalDown-RegulationExtracellular MatrixGlaucomaHumansHydrogen PeroxideMicroRNAsRatsRats, WistarTrabecular MeshworkUbiquitin-Protein LigasesHydrogen PeroxideMicroRNAsMIRN29a microRNA, humanMIRN29 microRNA, ratRNF138 protein, humanUbiquitin-Protein LigasesE3 ubiquitin‑protein ligase RNF138ERK pathwayglaucomamicroRNA‑29b‑3poxidative stress

Identifiers

PMID33907817
PMCPMC8054636
OpenAlexW3155198706

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.