Evidence map›Paper›PMID 33907749›Full record

ArticlebioRxiv : the preprint server for biology2021

Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19.

Lok-Yin Roy Wong, Jian Zheng, Kevin Wilhelmsen, Kun Li, Miguel E Ortiz, Nicholas J Schnicker, Alejandro A Pezzulo, Peter J Szachowicz, Klaus Klumpp, Fred Aswad and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 24 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Lok-Yin Roy Wong *Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
Jian Zheng *Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
Kevin WilhelmsenBIOAGE Labs, Richmond, CA 94804.
Kun LiDepartment of Pediatrics, University of Iowa, Iowa City, Iowa, USA.
Miguel E OrtizDepartment of Pediatrics, University of Iowa, Iowa City, Iowa, USA.
Nicholas J SchnickerProtein and Crystallography Facility, University of Iowa, Iowa City, Iowa, USA.
Alejandro A PezzuloDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Peter J SzachowiczDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Klaus KlumppBIOAGE Labs, Richmond, CA 94804.
Fred AswadBIOAGE Labs, Richmond, CA 94804.
Justin ReboBIOAGE Labs, Richmond, CA 94804.
Shuh NarumiyaDepartment of Drug Discovery Medicine, Kyoto University, Kyoto, Japan 606-8501.
Makoto MurakamiCenter for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
David K MeyerholzDepartment of Pathology, University of Iowa, Iowa City, Iowa, USA.
Kristen FortneyBIOAGE Labs, Richmond, CA 94804.
Paul B McCrayDepartment of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
Stanley PerlmanDepartment of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
University of Iowa · USKyoto University · JPThe University of Tokyo · JP

Funding

Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5M
SARS-CoV Proteins in Heterologous Viral InfectionP01AI060699 · NIAID · UNIVERSITY OF IOWA · PI PERLMAN, STANLEY · 2004 to 2021
$21.5M
TRAINING IN MECHANISMS OF PARASITISMT32AI007511 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WEBER, MARY · 1996 to 2025
$8.1M
Role of eicosanoids in pathogenic human CoV infectionsR01AI129269 · NIAID · UNIVERSITY OF IOWA · PI Stanley Perlman · 2016 to 2026
$4.7M
NIAID NIH HHS P01 AI060699NIAID NIH HHS R01 AI129269NIAID NIH HHS T32 AI007511NIDDK NIH HHS P30 DK054759
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is especially severe in aged populations

Indexed as

asapiprantCOVID-19pathogenesisprostaglandin D2SARS-CoV-2

Identifiers

PMID33907749
PMCPMC8077574
OpenAlexW3153235517

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.