ArticlePhysical review fluids2019
Liquid plug formation in an airway closure model.
Article in Physical review fluids, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Human lungs fluid mechanics: an overview of current modelling techniques.The European physical journal. E, Soft matter · 2026Review
- Insights into the fluid dynamics of bioaerosol formation in a model respiratory tract.Biomicrofluidics · 2024Article
- Effects of Kinematic Hardening of Mucus Polymers in an Airway Closure Model.Journal of non-Newtonian fluid mechanics · 2024Article
- Liquid plug propagation in computer-controlled microfluidic airway-on-a-chip with semi-circular microchannels.Lab on a chip · 2024Article
- Surfactant amplifies yield-stress effects in the capillary instability of a film coating a tube.Journal of fluid mechanics · 2023Article
- Splitting of a three-dimensional liquid plug at an airway bifurcation.Physics of fluids (Woodbury, N.Y. : 1994) · 2022Article
- Aerosol Transport Modeling: The Key Link Between Lung Infections of Individuals and Populations.Frontiers in physiology · 2022Review
- The effect of viscoelasticity in an airway closure model.Journal of fluid mechanics · 2021Article
- Effects of Surface Tension and Yield Stress on Mucus Plug Rupture: A Numerical Study.Journal of biomechanical engineering · 2020Article
- Biological fluid dynamics of airborne COVID-19 infection.Rendiconti Lincei. Scienze fisiche e naturali · 2020Review
- Impact of partial slip and lateral walls on peristaltic transport of a couple stress fluid in a rectangular duct.Science progressArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The closure of a human lung airway is modeled as an instability of a two-phase flow in a pipe coated internally with a Newtonian liquid. For a thick enough coating, the Plateau-Rayleigh instability creates a liquid plug which blocks the airway, halting distal gas exchange. Owing to a bi-frontal plug growth, this airway closure flow induces high stress levels on the wall, which is the location of airway epithelial cells. A parametric numerical study is carried out simulating relevant conditions for human lungs, either in ordinary or pathological situations. Our simulations can represent the physical process from pre- to post-coalescence phases. Previous studies have been limited to pre-coalescence only. The topological change during coalescence induces a high level of stress and stress gradients on the epithelial cells, which are large enough to damage them, causing sub-lethal or lethal responses. We find that post-coalescence wall stresses can be in the range of 300% to 600% greater than pre-coalescence values, so introduce a new important source of mechanical perturbation to the cells.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.