ArticleCancer management and research2021
Value of Combining Clinical Factors, Conventional Ultrasound, and Contrast-Enhanced Ultrasound Features in Preoperative Prediction of Central Lymph Node Metastases of Different Sized Papillary Thyroid Carcinomas.
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26 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Ultrasonography-Guided Thermal Ablation for Cervical Lymph Node Metastasis of Recurrent Papillary Thyroid Carcinoma: Is it Superior to Surgical Resection?Frontiers in endocrinology · 2022Pooled it
- Ultrasound-based nomogram for predicting central lymph node metastasis in papillary thyroid microcarcinoma.BMC endocrine disorders · 2026Article
- Dual-channel ultrasonic images empowered deep learning: significantly improving prediction of occult central lymph node metastases in solitary papillary thyroid microcarcinoma.Radiology and oncology · 2026Article
- An ultrasonographic tumor location-based model for predicting central lymph node metastasis in unifocal papillary thyroid microcarcinoma.Frontiers in endocrinology · 2026Observational
- Diagnostic performance of contrast-enhanced ultrasound vs. conventional ultrasound for lymph node metastasis in patients with thyroid cancer: A meta-analysis.Oncology letters · 2025Article
- A risk stratification model based on ultrasound radiologic features for cervical metastatic lymph nodes in papillary thyroid cancer.World journal of surgical oncology · 2025Article
- The Predictive Value of a Nomogram Based on Ultrasound Radiomics, Clinical Factors, and Enhanced Ultrasound Features for Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma.Ultrasonic imaging · 2025Article
- Development and validation of a dynamic nomogram for predicting central lymph node metastasis in papillary thyroid carcinoma patients based on clinical and ultrasound features.Quantitative imaging in medicine and surgery · 2025Article
- Article
- Arrival-Time Parametric Imaging in Contrast-Enhanced Ultrasound for Thyroid Nodule Differentiation.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Predictive Values of Clinical Features and Multimodal Ultrasound for Central Lymph Node Metastases in Papillary Thyroid Carcinoma.Diagnostics (Basel, Switzerland) · 2024Review
- Association between different regional lymph node metastases of papillary thyroid carcinoma in adolescents and young adults.Oncology letters · 2024Article
- Thyroid Cancer Central Lymph Node Metastasis Risk Stratification Based on Homogeneous Positioning Deep Learning.Research (Washington, D.C.) · 2024Article
- Factors influencing extrathyroidal extension of papillary thyroid cancer and evaluation of ultrasonography for its diagnosis: a retrospective analysis.Scientific reports · 2023Article
- Management of surgical diseases of thyroid gland indications of the United Italian Society of Endocrine Surgery (SIUEC).Updates in surgery · 2023Article
- PTC-MAS: A Deep Learning-Based Preoperative Automatic Assessment of Lymph Node Metastasis in Primary Thyroid Cancer.Diagnostics (Basel, Switzerland) · 2023Article
- Application of decision tree algorithms to predict central lymph node metastasis in well-differentiated papillary thyroid carcinoma based on multimodal ultrasound parameters: a retrospective study.Quantitative imaging in medicine and surgery · 2023Article
- Younger Than 55 Years Old andInternational journal of general medicine · 2023Article
- Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer.Cells · 2022Article
- Contrast-enhanced ultrasound characteristics of preoperative central cervical lymph node metastasis in papillary thyroid carcinoma.Frontiers in endocrinology · 2022Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeEarly and accurate preoperative diagnosis of central lymph node metastasis (CLNM) is crucial to improve surgical management of patients with clinical lymph node-negative papillary thyroid carcinoma (PTC). Towards improving diagnosis of CLNM, we assessed the value of combining preoperative clinical characteristics, conventional ultrasound, and contrast-enhanced ultrasound (CEUS) in preoperative prediction of CLNM of different sized PTCs. PATIENTS AND
methodsPatients were divided according to tumor size: a PTC group (>10 mm) and a papillary thyroid microcarcinoma (PTMC) group (≤10 mm). We retrospectively analyzed the clinical and ultrasonographic features of 120 PTC patients and 165 PTMC patients. Multivariate logistic regression analysis was used to screen independent risk factors and establish prediction models. Receiver operating characteristic curves were used to determine the best cut-off values for continuous variables and assess the performance of prediction models.
resultsIndependent risk predictors of CLNM for the PTC group were extrathyroidal extension in CEUS (OR=7.923), tumor size >14 mm (OR=5.491), and multifocality (OR=3.235). For the PTMC group, the independent risk factors were the distance from the thyroid capsule =0 mm (OR=4.629), male (OR=3.315), tumor size >5 mm (OR=3.304), and microcalcification (OR=2.560). The predictive model of combined method had better performance in predicting CLNM of PTC compared with models based on CEUS and conventional ultrasound alone (area under the curve: 0.832 vs 0.739,
conclusionThe predictive models of combined method obtained from significant preoperative clinical and ultrasonographic features can potentially improve the preoperative diagnosis and individual treatment of CLNM in patients with PTC and PTMC. CEUS may be helpful in predicting CLNM of PTC, but CEUS would be ineffective in predicting CLNM of PTMC.
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